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首页> 外文期刊>Journal of diabetes >Sodium glucose transporter 2 inhibition: A new approach to diabetes treatment
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Sodium glucose transporter 2 inhibition: A new approach to diabetes treatment

机译：钠葡萄糖转运蛋白2抑制:一个新的糖尿病治疗方法

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A vexing aspect of the treatment of type 2 diabetes is the potential of both insulin and the sulfonylureas to cause hypoglycemia, with increasing recognition of the association of hypoglycemia with adverse outcome. It is hypoglycemia rather than normalization of glycemic control that appears (for certain individuals) to be undesirable. Although in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study intensive glycemic treatment was associated with an increase in mortality, there was actual reduction in mortality with excellent control, with the dilemma that those diabetic patients in worse control initially appeared to have greater risk of both hypoglycemia and mortality. Thus, the appearance of a new therapeutic class not intrinsically associated with hypoglycemia should be greeted with cautious optimism. Glucose is present in the glomerular filtrate and is, under usual circumstances, completely reabsorbed by a group of transport proteins in the renal tubular epithelium, with sodium glucose transporter (SGLT)-2 quantitatively the most important.5 Recent observations have shown that diabetic patients upregulate the expression of this and other renal glucose transporters, presumably to compensate for and reduce glycosuria
机译：一个棘手的问题治疗2型糖尿病是胰岛素和的潜力磺酰脲类药物导致低血糖,增加协会的认可低血糖与不良的结果。低血糖而非正常化出现的血糖控制(对某些个人)是不可取的。控制糖尿病心血管风险行动(协议)研究强化血糖治疗与死亡率的增加有关,实际是减少死亡率的吗控制,与那些糖尿病的困境患者在控制最初似乎更糟糕有更大的风险和低血糖吗死亡率。治疗类不具有内在关联与低血糖应该谨慎相迎乐观。滤液,在通常情况下,完全吸收由一群的交通工具蛋白质在肾小管上皮钠葡萄糖转运体(SGLT) 2定量最important.5观测表明,糖尿病患者这和其他肾移植表达式葡萄糖转运蛋白,大概是为了补偿和减少糖尿

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