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首页> 外文期刊>Clinical advances in hematology & oncology: H&O >Cancer of unknown primary site: evolving understanding and management of patients.
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Cancer of unknown primary site: evolving understanding and management of patients.

机译：原发部位不明的癌症:进化理解和管理病人。

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摘要

Cancer of unknown primary site is a common clinicopathologic syndrome representing a very heterogeneous group of patients with metastatic cancers and clinically undetectable primary tumor sites. The standard treatment for these patients for the last 15 years has been empiric "broad-spectrum" chemotherapy. In recent years, improved immunocytochemistry and the emergence of gene expression profiling have provided the diagnostic tools necessary to accurately define the tissue of origin in the majority of patients. Recent data have confirmed the ability of molecular profiling assays to complement standard pathologic diagnosis, and a large prospective study has documented a survival improvement for patients treated with site-specific therapy directed by the molecular assay diagnoses of their tissues of origin compared to empiric chemotherapy. The clinicopathologic evaluation of patients is now more standardized. The era of empiric chemotherapy administered to all patients is coming to an end, and customized therapies are favored. The management of patients has evolved with the ability to confidently define the tissue of origin. Further delineation of the molecular aberrations in advanced solid tumors, regardless of the primary tumor site, signals a more precise and perhaps more effective therapy for each patient.
机译：原发部位不明的癌症是一种常见的代表一个临床病理综合征异质群体的转移患者癌症和临床检测的原发肿瘤网站。在过去的15年里一直经验“广谱”化疗。改进的免疫细胞化学和的出现基因表达分析提供了诊断工具需要精确定义大多数病人的组织起源。最近的数据已经证实的能力分子分析化验补充标准病理诊断和前瞻性研究已经记录了生存的改进患者特有的治疗执导的分子分析诊断其组织的起源与经验相比化疗。病人现在更标准化。所有患者化疗经验管理即将结束,和定制的疗法是什么青睐。与自信地定义组织的能力原产地。无论如何,畸变在先进的实体肿瘤原发肿瘤的网站,更准确的信号和更有效的治疗病人。

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