Purpose: Race-adjusted interpretation of data from Cirrus high-definition OCT (HD-OCT) devices is not standard practice. The aim of this study is to evaluate differences in peripapillary retinal nerve fiber layer (RNFL) thickness between healthy Black Americans and the Cirrus HD-OCT normative database. Design: This is a cross-sectional observational study using control patients recruited from the greater Philadelphia, Pennsylvania, area. Participants: A total of 466 eyes were included in this study. Subjects were retrospectively identified from the control cohort of the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study. Methods: Using an age-stratified or linear regression method, we reclassified white-green-yellow-red color probability codes for RNFL thicknesses by quadrant. Main Outcome Measures: The distribution of reclassified color codes was compared with the expected 5%-90%-4%-1 % percentiles and to the original color codes by the Cirrus machine.
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