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首页> 外文期刊>Ophthalmology. Glaucoma. >Effects of Postoperative Intravitreal Injections on Outcomes of Traditional Glaucoma Surgery in Patients with Preoperative Intravitreal Injections
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Effects of Postoperative Intravitreal Injections on Outcomes of Traditional Glaucoma Surgery in Patients with Preoperative Intravitreal Injections

机译：术后Intravitreal注入的影响在传统青光眼手术的结果患者术前Intravitreal注射

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Purpose: To compare outcomes of glaucoma drainage device (GDD) implantation and trabeculectomies with and without postoperative intravitreal injections (IVIs) in glaucoma patients with a history of preoperative IVIs. Design: Retrospective cohort study. Participants: A total of 133 eyes of 133 glaucoma patients who underwent GDD implantation or trabecu-lectomy with at least 1 IVI preoperatively between January 2005 and October 2020 at Massachusetts Eye and Ear. Methods: Chart review of glaucoma patients with traditional glaucoma surgery and at least 1 IVI before surgery. All statistical analyses were conducted with R statistical programming software. Main Outcome Measures: Intraocular pressure (IOP), medication burden, best-corrected visual acuity (BCVA), Kaplan-Meier success rates, adjusted hazard ratios (HRs), and complications. Results: Baseline demographics were similar between the groups with and without postoperative IVIs. The group with postoperative IVIs had a higher proportion of diabetic retinopathy and retinal vascular occlusions than the group without postoperative IVIs, which had more eyes with age-related macular degeneration. Intraocular pressure, medication burden, and visual acuity were similar between groups at all time points except for IOP at 6 weeks, which was lower in the group with postoperative IVIs. The group with postoperative IVIs had significantly more preoperative IVIs than the group without postoperative IVIs (6.6 vs. 3.3, P = 0.017). For success defined as IOP reduction > 20% with 5 < IOP < 21 mmHg, Kaplan-Meier analyses demonstrated similar success rates between groups with and without IVIs. When stratified by the number of IVIs, success rates for the group with 7 or more IVIs were significantly higher than the success rates for the group with 0-6 IVIs (P = 0.005). Each additional postoperative IVI resulted in a 7.2% decrease in the hazard of failure to achieve our stated success criteria. With regard to late complications, the group with postoperative IVIs had a higher incidence of vitreous hemorrhage (18.5% vs. 3.2%, P = 0.039) than the group without postoperative IVIs. Conclusions: A higher number of postoperative IVIs, specifically 7 or more IVIs, may be associated with improved success rates of traditional glaucoma surgery in glaucoma patients who received IVIs before surgery. Ophthalmology Glaucoma 2022;5:219-228 2021 by the American Academy of Ophthalmology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
机译：目的:比较的结果青光眼引流设备(GDD)植入和小梁切除术有和没有术后intravitreal注射(新)青光眼患者术前新历史。回顾性队列研究。133年133眼青光眼患者经历了GDD植入或trabecu-lectomy至少有1个新术前之间2005年1月至2020年10月在马萨诸塞州眼睛和耳朵。传统青光眼手术,患者1新手术前。与R统计进行了分析编程软件。眼内压(IOP),药物负担,最佳矫正视力(BCVA), kaplan meier成功率,调整风险比率(小时)并发症。类似的团体之间,没有吗术后新。新有较高比例的糖尿病视网膜病变和视网膜血管遮挡组术后无新,更多的与年龄相关性黄斑变性的眼睛。眼压、药物负担和视力组间相似在6周时间点除了眼压低与术后新集团。组术后新明显术前新多集团术后新(6.6 vs 3.3, P = 0.017)。成功定义为降低IOP > 20%和5

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