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首页> 外文期刊>Archives of Neurology >Association between paroxysmal tonic spasms and neuromyelitis optica.
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Association between paroxysmal tonic spasms and neuromyelitis optica.

机译：阵发性强直性痉挛和之间的联系neuromyelitis optica。

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OBJECTIVE: To determine the frequency of the association between tonic spasms and neuromyelitis optica (NMO) at our center. DESIGN: An institutional review board-approved retrospective study of clinical, serological, and radiographic characteristics of patients with NMO. SETTING: Multiple sclerosis center. PATIENTS: Patients with NMO treated at our center between 1990 and 2008. MAIN OUTCOME MEASURE: Records were examined for documentation of tonic spasms. RESULTS: Of 110 patients with International Classification of Diseases code 341, 57 patients met diagnostic criteria for NMO. Of these, 8 patients (14%) had documented typical tonic spasms (median age at onset, 39.5 years; range, 13.8-54.2 years). Of those patients, 4 were African American, 3 were Hispanic, and 1 was white. Only 1 was male. The NMO-IgG antibody was found in 1 of 6 patients tested. Tonic spasms appeared after a mean of 24.6 months (range, 0-91 months). In 2 of 57 patients meeting NMO criteria, tonic spasms accompanied their initial episodes. Seven of 8 patients who had tonic spasms responded to treatment with carbamazepine within 1 week. CONCLUSION: Tonic spasms are associated with NMO more commonly than with multiple sclerosis and may be a presenting sign in both diseases.
机译：目的:确定的频率强直性痉挛和之间的联系在我们的中心视neuromyelitis(动)。一个机构审查委员会批准了回顾性研究的临床、血清学和患者的影像学特征动。病人:动治疗患者在我们的中心在1990年和2008年之间。记录检查文档的补药痉挛。国际疾病分类代码341年,57例符合诊断标准的动。其中,8例(14%)有记录的典型强直性痉挛(中位发病年龄,39.5年;范围13.8 - -54.2年)。是非洲裔美国人,3是西班牙裔,和1是什么白色发现6例1的测试。出现后,平均24.6个月(范围0 - 91个月)。标准、强直性痉挛陪同他们最初的集。痉挛的反应与卡马西平治疗在1周之内。与动通常比有关多发性硬化和可能是一个迹象在这两种疾病。

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