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首页> 外文期刊>Venoms and Toxins >Inhibitory Effect of Carissa spinarum Linn Methanolic Leaf Extract Against Vipera russelli
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Inhibitory Effect of Carissa spinarum Linn Methanolic Leaf Extract Against Vipera russelli

机译：抑制作用的假虎刺属spinarum绝壁Methanolic叶提取物对Vipera russelli

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Background: Carissa spinarum Linn has been used as a traditional medicine to treat various ailments, including snakebite. It is found in India, Ceylon and Thailand. Objective: The study was performed to determine the inhibiting potential of Carissa spinarum methanolic leaf extract on the pharmacological effects of Viper venom. Methods: The dose-dependent enzymatic studies, pharmacological and in vivo studies were conducted using standard methods. Results: It neutralized toxic enzymes in a dose-dependent manner with concentrations ranging from 53.3 -1190.4 pg/mL, inhibited lysis of fibrinogen at 1:8 (venom: extract, w/w), and increased the procoagulant activity and lecithin lysis at 1:25 (venom: extract, w/w). The extract neutralized the LD50 of venom in mice and embryos, reduced haemorrhage, myotoxicity and edema induced by the venom in mice. Conclusion: The observed results confirm that the leaf extract possesses adequate phytochemicals that could neutralize the toxic properties of the venom.
机译：背景:假虎刺属spinarum林已被用作传统医学治疗各种疾病,包括蛇咬伤。和泰国。确定抑制假虎刺属的潜力spinarum methanolic叶中提取的毒蛇的毒液的药理作用。酶存在剂量依赖的相关性研究,药理和体内研究使用标准方法进行。中和有害酶存在剂量依赖的相关性浓度从53.3-1190.4 pg / mL,抑制细胞溶解的纤维蛋白原1:8(毒液:提取,w / w),并增加了促凝血的活动和卵磷脂在1:25消散(毒液:提取、w / w)。毒液在小鼠和胚胎的LD50,减少引发的出血、myotoxicity和水肿在老鼠身上的毒液。确认叶提取物具有足够了植物化学物质能够中和有毒毒液的属性。

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