• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Venoms and Toxins >Snake Venom Proteins Isolated from Tunisian Vipers: Pharmacological and Therapeutic Overview
【24h】

Snake Venom Proteins Isolated from Tunisian Vipers: Pharmacological and Therapeutic Overview

机译：从突尼斯蛇毒蛋白分离毒蛇:药理和治疗概述

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The venoms of Tunisian wildlife snakes are complex mixtures containing pro-teins/peptides and non-protein molecules. Proteins and peptides are the most abundant compounds responsible for the biological effects of venoms. Snake venoms proteins have enzymatic or non-enzymatic activities, which are grouped into different families, including C-type lectin proteins, disintegrins (long, medium and short disintegrins), Kunitz-type serine protease inhibitors, natri-uretic-like peptides, vascular endothelial growth factor-related proteins, L-amino acid oxidases, phospholipases A2 and serine proteinases. With technological advancements, the toxic effects of venoms were turned into potential benefits for clinical diagnosis, basic research and development of new research tools and drugs of potential clinical use. Our research team has shown that Macrovipera lebetina and Cerastes cerastes venom components of Tunisian wildlife snakes had great potential for the development of new drugs for the treatment of cancer, angiogenesis disorders or cardiovascular diseases. This review is an overview of snake venom proteins from Macrovipera lebetina and Cerastes cerastes and their biochemical, pharmacological and molecular characterization and their importance as protein resources with therapeutic potential.
机译：突尼斯野生动物蛇的毒液是复杂的包含pro-teins /肽混合物非蛋白分子。负责最丰富的化合物毒液的生物效应。蛋白质酶或non-enzymatic活动,分组到不同的家庭,包括c型凝集素蛋白,disintegrins(长、中、短disintegrins), Kunitz-type丝氨酸蛋白酶抑制剂,natri-uretic-like肽、血管内皮生长factor-related蛋白质,L-amino酸氧化酶类、磷脂酶A2和丝氨酸蛋白酶。进步,毒液的毒性作用为临床变成潜在的好处新的诊断、基础研究和发展研究工具和药物的潜在临床使用。lebetina和角蝰角蝰毒液组件突尼斯野生动物蛇有巨大的潜力为新药的开发癌症治疗、血管生成障碍心血管疾病。从Macrovipera蛇毒蛋白的概述lebetina和角蝰角蝰和他们生化、药理和分子表征蛋白质及其重要性资源与治疗的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号