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首页> 外文期刊>Archives of Neurology >Measuring demyelination and remyelination in acute multiple sclerosis lesion voxels.
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Measuring demyelination and remyelination in acute multiple sclerosis lesion voxels.

机译：测量在急性脱髓鞘和remyelination多发性硬化病变体素。

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摘要

OBJECTIVE: To validate the use of the magnetization transfer ratio (MTR) as a practical imaging marker of demyelination and remyelination in acute multiple sclerosis lesions. DESIGN: Case study. SETTING: University hospital multiple sclerosis clinic. Patients Six patients with relapsing-remitting multiple sclerosis and acute gadolinium-enhancing lesions were studied serially using a quantitative magnetization transfer examination. MAIN OUTCOME MEASURES: Changes in the water content and macromolecular content, a marker of myelin content that, unlike MTR, is not affected by changes in water content (edema) associated with acute inflammation, and changes in MTR of lesions. RESULTS: Both the macromolecular content and MTR were lower than normal in acute lesions and recovered over several months. The decrease in macromolecular content relative to contralateral normal-appearing white matter was greater than the decrease in MTR (0.46 vs 0.75 at the time of gadolinium enhancement), likely because edema in the acute lesion increased the T1 relaxation time of water and attenuated the decrease in MTR. Nevertheless, there was still a strong correlation between changes in the relative MTR and macromolecular content (R(2) = 0.70; P < .001). CONCLUSION: Our data support the use of MTR as a practical marker of demyelination and remyelination, even in acute lesions where decreases in MTR are attenuated because of the effects of edema.
机译：目的:验证的使用磁化传递率(地铁)作为实用成像的髓鞘脱失和remyelination标志在急性多发性硬化病变。研究。硬化诊所。复发缓和多发性硬化和急性钆增强病变进行了研究连续使用定量磁化转移考试。含水量的变化和大分子内容、髓鞘的一个标志内容,与地铁,不受含水量的变化(水肿)与急性炎症有关,和地铁的病变的变化。大分子和地铁都低于内容在急性损伤和恢复正常好几个月。内容相对于侧大于正常白质减少地铁(0.46 vs 0.75的时候钆增强),可能因为水肿急性损伤增加了T1弛豫时间水和减毒的减少地铁。尽管如此,仍有一股强烈的变化之间的相关性相对地铁和大分子内容(R (2) = 0.70;措施)。地铁作为一个实际的髓鞘脱失和标志remyelination,甚至在急性病变减少在地铁减毒的水肿的影响。

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