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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Laminin-1-adherent cancer cells show increased proliferation and decreased apoptosis in vivo.
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Laminin-1-adherent cancer cells show increased proliferation and decreased apoptosis in vivo.

机译：层粘连蛋白-1粘附的癌细胞在体内显示出增加的增殖和减少的凋亡。

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BACKGROUND: The growth rate of a tumor is dependent on both cell proliferation and cell loss. We have established subpopulations of human colon cancer cells with different in vivo growth rates by selecting the cells according to their adhesiveness to laminin-1 in vitro. MATERIALS AND METHODS: Laminin-1-adhesion selected colon cancer cells were injected into the cecal wall of nude mice. The tumors were examined 30 days later. Cell proliferation was assessed by proliferating cell nuclear antigen (PCNA) index and apoptotic cells were labeled by digoxigenin-11-dUTP using terminal deoxynucleotidyl transferase. RESULTS: The laminin-1-adherent cells, which formed larger tumors in vivo, showed increased proliferative activity and reduced apoptosis in comparison with the laminin-1-nonadherent cells. CONCLUSION: Laminin-1 may enhance the malignant behavior of colon cancer cells by accelerating proliferation as well as by decreasing cell loss.
机译：背景：肿瘤的生长速度取决于细胞增殖和细胞损失。通过根据体外对层粘连蛋白-1的粘附性选择细胞，我们建立了具有不同体内生长速率的人结肠癌细胞亚群。材料与方法：将层粘连蛋白1粘附选择的结肠癌细胞注入裸鼠的盲肠壁。 30天后检查肿瘤。通过增殖细胞核抗原（PCNA）指数评估细胞增殖，并使用末端脱氧核苷酸转移酶通过地高辛配基-11-dUTP标记凋亡细胞。结果：与层粘连蛋白-1非粘附细胞相比，层粘连蛋白1粘附细胞在体内形成较大的肿瘤，其增殖活性增强，凋亡减少。结论：层粘连蛋白-1可能通过加速增殖以及减少细胞损失来增强结肠癌细胞的恶性行为。

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