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首页> 外文期刊>Acta crystallographica.Section D Biological crystallography. >Lysine carboxylation: Unveiling a spontaneous post-translational modification
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Lysine carboxylation: Unveiling a spontaneous post-translational modification

机译：赖氨酸羧化作用:推出一个自发的翻译修饰

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摘要

The carboxylation of lysine residues is a post-translational modification (PTM) that plays a critical role in the catalytic mechanisms of several important enzymes. It occurs spontaneously under certain physicochemical conditions, but is difficult to detect experimentally. Its full impact is unknown. In this work, the signature microenvironment of lysine-carboxylation sites has been characterized. In addition, a computational method called Predictor of Lysine Carboxylation (PreLysCar) for the detection of lysine carboxylation in proteins with available three-dimensional structures has been developed. The likely prevalence of lysine carboxylation in the proteome was assessed through large-scale computations. The results suggest that about 1.3% of large proteins may contain a carboxylated lysine residue. This unexpected prevalence of lysine carboxylation implies an enrichment of reactions in which it may play functional roles. The results also suggest that by switching enzymes on and off under appropriate physicochemical conditions spontaneous PTMs may serve as an important and widely used efficient biological machinery for regulation.
机译：赖氨酸残基的羧化作用翻译修饰(天车)的催化机制的重要作用几个重要的酶。自发地在某些物理化学条件,但很难发现实验。这项工作,签名的微环境lysine-carboxylation网站已为特征。方法称为赖氨酸羧化作用的预测(PreLysCar)赖氨酸的检测羧化作用的蛋白质三维结构。可能流行的赖氨酸羧化作用通过大规模蛋白质组进行评估计算。大量蛋白质可能含有羧酸盐赖氨酸残基。赖氨酸羧化作用意味着的浓缩反应中,它可以发挥功能作用。结果还表明,通过切换酶开关在适当物理化学条件下自发天车作为一个重要的和广泛使用的高效生物机械的监管。

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