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首页> 外文期刊>Acta crystallographica.Section D Biological crystallography. >Structure of the TRAF4 TRAF domain with a coiled-coil domain and its implications for the TRAF4 signalling pathway
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Structure of the TRAF4 TRAF domain with a coiled-coil domain and its implications for the TRAF4 signalling pathway

机译：结构的TRAF4 TRAF域了卷曲螺旋域及其影响TRAF4信号通路

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摘要

The TNF receptor-associated factor (TRAF) proteins are structurally similar scaffold proteins that mediate between members of the TNF receptor (TNFR) family and downstream effector molecules such as kinases in the immune signalling pathway. Seven TRAFs have been identified, including TRAF4, which is a unique member that participates in many ontogenic processes, including nerve-system development. TRAFs commonly contain the TRAF domain, which mediates interaction with target receptors and effectors. As a first step towards elucidating the molecular mechanisms of the TRAF4-mediated signalling pathway, the first crystal structure of the human TRAF4 TRAF domain with a coiled-coil domain is reported at 2.3 ? resolution.
机译：肿瘤坏死因子receptor-associated因素(TRAF)的蛋白质结构类似的支架蛋白吗协调成员之间的肿瘤坏死因子受体家人(TNFR)和下游效应分子如激酶免疫信号通路。七TRAFs已确定,包括TRAF4,这是一个独特的成员参与在很多个体发育的过程,包括神经系统的发展。TRAF域,协调交互目标受体和效应器。分子机制的阐明TRAF4-mediated信号通路,第一晶体结构的人类TRAF4 TRAF域在2.3的卷曲螺旋域是报道吗?决议。

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