Structures of human cytosolic and mitochondrial nucleotidases: Implications for structure-based design of selective inhibitors

PachlP.; FábryM.; RosenbergI.?imákO.?ezá?ováP.BryndaJ.

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Structures of human cytosolic and mitochondrial nucleotidases: Implications for structure-based design of selective inhibitors

机译：人类胞质和线粒体的结构核苷酸酶:对基于结构的影响设计的选择性抑制剂

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The human 5′(3′)-deoxyribonucleotidases catalyze the dephos-phorylation of deoxyribonucleoside monophosphates to the corresponding deoxyribonucleosides and thus help to maintain the balance between pools of nucleosides and nucleotides. Here, the structures of human cytosolic deoxy-ribonucleotidase (cdN) at atomic resolution (1.08 ?) and mitochondrial deoxyribo-nucleotidase (mdN) at near-atomic resolution (1.4 ?) are reported. The attainment of an atomic resolution structure allowed interatomic distances to be used to assess the probable protonation state of the phosphate anion and the side chains in the enzyme active site. A detailed comparison of the cdN and mdN active sites allowed the design of a cdN-specific inhibitor.

机译：人类5 (3)-deoxyribonucleotidases催化的dephos-phorylation脱氧核苷一磷酸到相应的脱氧核苷,从而有助于维护池的核苷和之间的平衡核苷酸。胞质deoxy-ribonucleotidase (cdN)在原子分辨率(1.08 ?)和线粒体在near-atomic deoxyribo-nucleotidase (mdN)报告决议(1.4 ?)。一个原子分辨率结构允许的原子间的距离是用来评估可能的磷酸盐阴离子的质子化作用状态和侧链酶活性部位。cdN和mdN详细比较活跃网站允许cdN-specific的设计抑制剂。

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来源
《Acta crystallographica.Section D Biological crystallography.》 |2014年第2期|461-470|共10页
作者
PachlP.; FábryM.; RosenbergI.?imákO.?ezá?ováP.BryndaJ.;
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作者单位

Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám;

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i.,;

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正文语种英语
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关键词
NT5C gene; Nucleosides; BASES(STRUCTURES)Cytosolenzyme inhibitionDeoxyribonucleosidesNucleotidasesMitochondriafundamental design;

机译：(结构)Cytosolenzyme基因;核苷;基地;

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Structures of human cytosolic and mitochondrial nucleotidases: Implications for structure-based design of selective inhibitors

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