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首页> 外文期刊>Acta crystallographica.Section D Biological crystallography. >Conformational transitions in the γ subunit of the archaeal translation initiation factor 2
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Conformational transitions in the γ subunit of the archaeal translation initiation factor 2

机译：γ亚基的构象转变古细菌的翻译起始因子2

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摘要

In eukaryotes and archaea, the heterotrimeric translation initiation factor 2 (e/aIF2) is pivotal for the delivery of methionylated initiator tRNA (Met-tRNAi) to the ribosome. It acts as a molecular switch that cycles between inactive (GDP-bound) and active (GTP-bound) states. Recent studies show that eIF2 can also exist in a long-lived eIF2γ-GDP-Pi (inorganic phosphate) active state. Here, four high-resolution crystal structures of aIF2γ from Sulfolobus solfataricus are reported: aIF2γ-GDPCP (a nonhydrolyzable GTP analogue), aIF2γ-GDP-formate (in which a formate ion possibly mimics Pi), aIF2γ-GDP and nucleotide-free aIF2γ. The structures describe the different states of aIF2γ and demonstrate the conformational transitions that take place in the aIF2γ 'life cycle'.
机译：在真核生物和古菌,heterotrimeric翻译起始因子2 (e / aIF2)关键methionylated交付的发起者tRNA核糖体(Met-tRNAi)。作为一个周期之间的分子开关不活跃(蛋白)和活动(GTP-bound)州。存在于一个长寿eIF2γ-GDP-Pi(无机磷酸)活动状态。高分辨率的晶体结构aIF2γ硫化叶菌solfataricus报告:aIF2γ-GDPCP(nonhydrolyzable三磷酸鸟苷类似物),aIF2γ-GDP-formate甲酸(其中一个离子可能模仿π),aIF2γgdpnucleotide-free aIF2γ。不同州的aIF2γ和演示发生构象的转变aIF2γ“生命周期”。

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