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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2
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Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2

机译：结构多态性L1循环的区域人类H2A.Z。

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摘要

The histone H2A.Z variant is widely conserved among eukaryotes. Two isoforms, H2A.Z.1 and H2A.Z.2, have been identified in vertebrates and may have distinct functions in cell growth and gene expression. However, no structural differences between H2A.Z.1 and H2A.Z.2 have been reported. In the present study, the crystal structures of nucleosomes containing human H2A.Z.1 and H2A.Z.2 were determined. The structures of the L1 loop regions were found to clearly differ between H2A.Z.1 and H2A.Z.2, although their amino-acid sequences in this region are identical. This structural polymorphism may have been induced by a substitution that evolutionally occurred at the position of amino acid 38 and by the flexible nature of the L1 loops of H2A.Z.1 and H2A.Z.2. It was also found that in living cells nucleosomal H2A.Z.1 exchanges more rapidly than H2A.Z.2. A mutational analysis revealed that the amino-acid difference at position 38 is at least partially responsible for the distinctive dynamics of H2A.Z.1 and H2A.Z.2. These findings provide important new information for understanding the differences in the regulation and functions of H2A.Z.1 and H2A.Z.2 in cells.
机译：组蛋白H2A。在真核生物中。H2A.Z。可能有不同的细胞生长和功能吗基因的表达。H2A.Z之间的区别。报道。核小体结构包含人类H2A.Z。结构L1循环的地区被发现显然H2A.Z之间的不同。虽然他们的氨基酸序列区域是相同的。多态性可能是诱导的散播他们的替换发生的氨基酸的位置38和灵活H2A.Z L1循环的性质。还发现,在活细胞nucleosomal吗H2A.Z。突变分析表明氨基酸不同位置38至少部分负责的独特的动态H2A.Z。为了解重要的新信息的监管和功能的差异H2A.Z。

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