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首页> 外文期刊>Acta crystallographica. Section D, Biological crystallography. >Expectation bias and information content
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Expectation bias and information content

机译：期望偏差和信息内容

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摘要

It has long been realised that the interpretation of macromolecular structures from electron-density maps involves some degree of subjectivity (Branden & Jones, 1990). This is a direct consequence of factors such as limited data resolution or inherent disorder, in solvent regions, in segments of a macromolecule, or in a bound ligand. Whereas the well behaved parts of the structure may often be confidently interpreted, and often refined completely automatically without human intervention, in practice there are usually some regions that require very careful inspection and interpretation by the experienced scientist. Often such difficult-to-interpret features are simultaneously the most important in the context of chemistry and biology, as with, for example, biologically active ligands interacting with enzymes or receptors.
机译：它一直被意识到的解释大分子的结构电子密度地图涉及某种程度的主体性(Branden &琼斯,1990)。的直接后果等因素限制数据分辨率或固有的障碍,在溶剂地区,在高分子的片段,或在一个配体。结构往往可能是自信完全解释,常常和细化没有人工干预,自动实践通常有一些地区需要非常仔细的检查解释的经验丰富的科学家。通常这些难以解释的特性同时最重要的上下文化学和生物学的,例如,生物活性配体相互作用酶或受体。

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