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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Structure of the Triatoma virus capsid
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Structure of the Triatoma virus capsid

机译：Triatoma病毒衣壳结构

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摘要

The members of the Dicistroviridae family are non-enveloped positive-sense single-stranded RNA (+ssRNA) viruses pathogenic to beneficial arthropods as well as insect pests of medical importance. Triatoma virus (TrV), a member of this family, infects several species of triatomine insects (popularly named kissing bugs), which are vectors for human trypanosomiasis, more commonly known as Chagas disease. The potential use of dicistroviruses as biological control agents has drawn considerable attention in the past decade, and several viruses of this family have been identified, with their targets covering honey bees, aphids and field crickets, among others. Here, the crystal structure of the TrV capsid at 2.5 14;? resolution is reported, showing that as expected it is very similar to that of Cricket paralysis virus (CrPV). Nevertheless, a number of distinguishing structural features support the introduction of a new genus (Triatovirus; type species TrV) under the Dicistroviridae family. The most striking differences are the absence of icosahedrally ordered VP4 within the infectious particle and the presence of prominent projections that surround the fivefold axis. Furthermore, the structure identifies a second putative autoproteolytic DDF motif in protein VP3, in addition to the conserved one in VP1 which is believed to be responsible for VP0 cleavage during capsid maturation. The potential meaning of these new findings is discussed.
机译：Dicistroviridae家族的成员无包膜积极意义单链RNA(+ ssRNA)病毒致病性有益的节肢动物和害虫的医疗的重要性。这个家庭,感染数种锥蝽昆虫(通常叫接吻错误),这是人类的向量锥虫病,俗称恰加斯疾病。生物防治剂引起了相当大的注意在过去的十年里,和几个病毒这个家庭已确定,与他们目标蜜蜂、蚜虫和字段蟋蟀等等。在2.5 14;结构和衣壳吗?解析报告,显示它非常类似于板球瘫痪病毒(CrPV)。区分结构特性的支持引入一个新的属(Triatovirus;物种和)下Dicistroviridae家庭。最显著的差别是没有的二十面体下令VP4在传染性粒子和突出的存在预测5倍轴周围。此外,结构确定假定的autoproteolytic地区指定基金主题的蛋白质VP3,除了守恒的VP1这被认为是负责VP0衣壳成熟期间乳沟。这些新发现的意义进行了探讨。

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