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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata
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Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata

机译:产品在lumazine合成酶催化从真菌病原体念珠菌glabrata

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摘要

Candida glabrata has emerged as an important fungal pathogen with intrinsic resistance to azole drugs. The limited efficacy of and resistance to existing antifungals is driving the need to identify new drug targets. The enzyme 6,7-dimethyl-8-(d-ribityl)lumazine synthase is part of the riboflavin- biosynthesis pathway essential to fungi and bacteria and is a potential drug target for the development of broad-spectrum antifungal drugs. The X-ray crystal structure of recombinant lumazine synthase from C. glabrata was obtained at 2.24 ? resolution and revealed a dimer of homopentamers, with one in five subunits containing a product molecule from the catalytic reaction.
机译:假丝酵母glabrata已成为一个重要的真菌病原体与内在阻力唑药物。电阻是推动现有的抗真菌治疗需要确定新的药物靶点。(6, 7-dimethyl-8) - d-ribityl lumazine合成酶核黄素-生物合成途径的一部分真菌和细菌,是必不可少的潜在的药物的发展目标广谱抗真菌药物。重组lumazine的晶体结构合酶从c . glabrata获得2.24吗?分辨率和显示homopentamers的二聚体,有五分之一的子单元包含一个产品催化反应的分子。

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