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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond.
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The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond.

机译：的结构Bach2 POZ-domain二聚体展现了一个intersubunit二硫键。

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摘要

Bach2 is a transcriptional repressor that is expressed during specific stages of B-cell development and in neuronal cells. It plays a critical role in modulating class-switch recombination during the differentiation of mature B cells to antibody-secreting plasma cells and it is also an important regulator of apoptotic responses to oxidative stress. Bach2 has been implicated both as an oncogene and as a tumour suppressor in human malignancy. The interaction of Bach2 with its target genes is mediated via its basic leucine-zipper region, whereas the N-terminal POZ domain recruits transcriptional co-repressors and class II histone deacetylases. Here, the crystal structure of the human Bach2 POZ domain is reported at 2.1 A resolution. The Bach2 POZ-domain dimer resembles the POZ-domain dimers of the POZ zinc finger transcription factors and dimerization is independent of an N-terminal region that has previously been implicated in the dimerization of the POZ basic leucine-zipper protein Bach1. The Bach2 POZ domain crystallized in two forms which differed by the presence of an intersubunit disulfide bond. The intersubunit disulfide bond is present both in bacterially expressed Bach2 POZ domain in solution and in protein expressed in transfected eukaryotic cells. These crystal structures will be relevant for understanding the regulation of Bach2 in response to oxidative stress and for the design of therapeutics that target the Bach2 POZ domain in human malignancy.
机译：Bach2是一个转录抑制因子表示在特定阶段的b细胞发展和神经细胞。在调节级调节至关重要的作用在分化重组成熟的B细胞antibody-secreting浆细胞它也是一个重要的监管机构凋亡对氧化应激的反应。已经涉及作为癌基因和作为在人类恶性肿瘤抑制基因。互动Bach2目标基因介导通过其基本leucine-zipper地区,而氨基POZ域新兵转录体若和二类组蛋白去乙酰酶抑制剂。人类Bach2 POZ域是报道为2.1一项决议。类似于POZ-domain POZ锌二聚体手指转录因子和二聚作用独立的氨基端地区之前被卷入的二聚作用Bach1 POZ基本leucine-zipper蛋白质。Bach2 POZ域结晶两种形式一个intersubunit不同的存在二硫键。出现在细菌表达Bach2POZ域解决方案和蛋白表达在转染真核细胞。结构相关的理解监管Bach2氧化的反应压力和设计的疗法针对Bach2 POZ域在人类恶性肿瘤。

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