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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Crystallographic analysis of the conserved C-terminal domain of transcription factor Cdc73 from Saccharomyces cerevisiae reveals a GTPase-like fold
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Crystallographic analysis of the conserved C-terminal domain of transcription factor Cdc73 from Saccharomyces cerevisiae reveals a GTPase-like fold

机译：晶体的守恒的分析转录因子Cdc73 c端域的从酿酒酵母显示GTPase-like褶皱

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摘要

The yeast Paf1 complex (Paf1C), which is composed of the proteins Paf1, Cdc73, Ctr9, Leo1 and Rtf1, accompanies RNA polymerase II from the promoter to the 3′-end formation site of mRNA- and snoRNA-encoding genes. As one of the first identified subunits of Paf1C, yeast Cdc73 (yCdc73) takes part in many transcription-related processes, including binding to RNA polymerase II, recruitment and activation of histone-modification factors and communication with other transcriptional activators. The human homologue of yCdc73, para-fibromin, has been identified as a tumour suppressor linked to breast, renal and gastric cancers. However, the functional mechanism of yCdc73 has until recently been unclear. Here, a 2.2 ? resolution crystal structure of the highly conserved C - terminal region of yCdc73 is reported. It revealed that yCdc73 appears to have a GTPase-like fold. However, no GTPase activity was observed. The crystal structure of yCdc73 will shed new light on the modes of function of Cdc73 and Paf1C.
机译：酵母Paf1复杂(Paf1C)组成的蛋白质Paf1 Cdc73、Ctr9 Leo1 Rtf1,伴随着从启动子RNA聚合酶II3 '端形成mRNA,snoRNA-encoding基因。Paf1C识别单元,酵母Cdc73许多transcription-related (yCdc73)参加流程,包括绑定RNA聚合酶第二,招聘和激活histone-modification因素和沟通与其他转录激活物。同系物的yCdc73 para-fibromin,作为一个肿瘤抑制基因与识别乳腺癌、肾和胃癌症。yCdc73直到最近的功能机制是不清楚。结构高度保守的C -末端地区yCdc73报道。yCdc73似乎GTPase-like褶皱。然而,没有观察到GTPase活性。yCdc73将揭示的晶体结构Cdc73和Paf1C模式的功能。

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