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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Continuous β-turn fold of an alternating alanyl/homoalanyl peptide nucleic acid
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Continuous β-turn fold of an alternating alanyl/homoalanyl peptide nucleic acid

机译：连续β词交替的褶皱丙氨酰/ homoalanyl肽核酸

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摘要

The crystal structure of the PNA (peptide nucleic acid) oligomer H-Lys-HalG-AlaG-HalC-AlaG-HalC-AlaC-Lys-NH2 (PNA1, amino acids with d-configuration are underlined, Ala = alanyl, Hal = homoalanyl) has been determined by ab initio direct methods and refined against 1.0 ?data. The asymmetric unit consists of a tetrameric cage with almost ideal Watson-Crick C-G base pairing of all the guanine and cytosine side-chain substituents. Each PNA strand has a 90°Β-turn every second residue, stabilized by three hydrogen bonds between the backbone amides. The first, second, fifth and sixth bases stack on one side of the monomer and pair with the corresponding complementary bases of a second monomer to form a dimer. The two remaining bases on each side of the resulting dimer form Watson-Crick pairs with the complementary bases of a second dimer, leading to a unique cage structure. The extra methylene groups in the homoalanyl residues enable stacking of the bases with an optimal distance between base-planes but also with an appreciable lateral displacement (slide).
机译：机构的晶体结构(肽核酸酸)低聚物(PNA1氨基酸与维强调,阿拉巴马州=丙氨酰,哈尔= homoalanyl)是由直接方法和从头开始针对1.0 ?数据的提炼。由一个四聚物的笼子里几乎理想沃森克里克c g碱基配对的鸟嘌呤和胞嘧啶取代基侧链。链有一个90°Β词每秒钟残留物,由三个氢键之间的稳定酰胺支柱。第六个基地堆栈的一侧单体和搭配相应的互补的基地第二单体形成二聚体。剩余的基地两侧产生的二聚体形式的沃森克里克成对的补充基地的二聚体,从而导致一个独特的笼形结构。组织homoalanyl残留物使堆积基地的最佳距离base-planes也具有明显的横向位移(幻灯片)。

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