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首页> 外文期刊>Archives of Neurology >Deep brain stimulation of the internal segment of the globus pallidus in delayed runaway dyskinesia.
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Deep brain stimulation of the internal segment of the globus pallidus in delayed runaway dyskinesia.

机译：脑深部电刺激的内部的延迟失控的苍白球运动障碍。

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BACKGROUND: Dyskinesias that occur during a period without medication after embryonic cell transplantation have been commonly reported in double-blind trials; however, to date, they have not been reported in the few patients who participated in open-label pilot studies. DESIGN: Single case observation with preoperative and postoperative data, and intraoperative single-cell physiology. PATIENT: A patient who underwent embryonic cell transplantation in 1993 as part of the University of South Florida open-label study was referred for evaluation of intractable dyskinesia of the right arm. The dyskinesia was present during evaluation of the patient after a 12-hour period without medication and was clinically disabling. It was manifested as a severe groping movement of the hand. Intraoperative physiologic evaluation revealed decreased firing rates in the internal segment of the globus pallidus. RESULTS: Deep brain stimulation of the internal segment of the globus pallidus resulted in resolution of the dyskinesia. CONCLUSION: This case highlights the delayed development of runaway dyskinesia after a period without medication as an important potential long-term adverse effect of embryonic cell transplantation in patients with Parkinson disease.
机译：背景:动作障碍发生的期间没有药物治疗后胚胎细胞移植已被广泛报道双盲试验;没有报告的几个病人参与开放试点研究。观察术前和单一的情况术后数据和术中单细胞的生理机能。在1993年接受胚胎细胞移植南佛罗里达大学的一部分开放研究被进行评估棘手的右手臂的运动障碍。在评估运动障碍出现没有药物治疗病人经过12个小时的时间临床上禁用。作为一个严重的摸索的手的运动。术中生理评估显示降低发射率的内部部分苍白球。刺激内部的球pallidus导致解决运动障碍。延迟后失控的运动障碍的发展没有药物作为一种重要的时期潜在的胚胎长期不利影响细胞移植在帕金森患者疾病。

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