...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of Neurology >Subthalamic stimulation in Parkinson disease: behavior and social adaptation.
【24h】

Subthalamic stimulation in Parkinson disease: behavior and social adaptation.

机译：丘脑下的刺激在帕金森病:行为和社会适应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Bilateral subthalamic high-frequency stimulation significantly improves motor functions in patients with advanced forms of Parkinson disease (PD). This favorable effect contrasts with a growing number of reports that the treatment may result in psychiatric complications. OBJECTIVE: To analyze the presence of behavioral disorders and social maladjustment in PD patients successfully treated with continuous bilateral subthalamic stimulation. DESIGN: Prospective study. SETTING: University hospital. METHODS: Twenty PD patients underwent prospective evaluation for behavioral and personality changes, quality of life, and social functioning, 6 and 24 months after surgery to implant bilateral stimulating electrodes within the subthalamic nucleus. RESULTS: At 6 and 24 months after surgery, parkinsonian motor disability (on-stimulation/off-medication) was improved by 81% and 67%, respectively, and the severity of levodopa-related motor complications was improved by 84% and 70%, respectively. Levodopa-equivalent dosage was decreased by 79% and 66%, respectively; severity of depression was improved by 21% and 33%, respectively; and severity of anxiety was improved by 43% and 64%, respectively. The patients' personality traits were unmodified. Twenty-four months after surgery, the global score for quality of life was improved by 28%, whereas scores for social adjustment remained stable. CONCLUSIONS: Provided that patients with PD are rigorously selected for neurosurgery, subthalamic stimulation (1) improves mood, anxiety, and quality of life; (2) does not result in severe permanent psychiatric disorders or modify patients' personality; and (3) does not ameliorate social adaptation.
机译：背景:双边丘脑下的高频刺激显著提高电动机患者的高级形式的功能帕金森病(PD)。与越来越多的报道,形成鲜明对比治疗可能导致精神病并发症。行为障碍和社交障碍PD患者成功地处理连续双边丘脑下的刺激。设计:前瞻性研究。医院。未来的行为和评价性格的改变,生活质量和社会功能,手术后6到24个月植入双边刺激电极底丘脑核。个月手术后,帕金森运动残疾(刺激/ off-medication)分别提高了81%和67%,levodopa-related运动并发症的严重性分别提高了84%和70%。Levodopa-equivalent剂量下降了79%分别为和66%;分别提高了21%和33%;焦虑的程度提高了43%和64%,分别。被修改的。手术,全球生活质量得分提高了28%,而分数为社会调整保持稳定。PD患者严格选择神经外科、丘脑下的刺激(1)改善情绪、焦虑和生活质量;不会导致严重的永久的精神疾病或修改病人的人格;(3)不改善社会适应。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号