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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >It's all in the crystals....
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It's all in the crystals....

机译：这都是在晶体……

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摘要

Macromolecular crystallography relies on the availability and quality of single crystals; these are typically obtained through extensive screening, which has a very low intrinsic success rate. Crystallization is not a completely stochastic process and many proteins do not succumb to crystallization because of specific microscopic features of their molecular surfaces. It follows that rational surface engineering through site-directed mutagenesis should allow a systematic and significant improvement in crystallization success rates. Here, one such established strategy, surface-entropy reduction (SER), is discussed, including its successes, limitations and possible future developments.
机译：大分子晶体学依赖可用性和质量的单一晶体;这些通常是通过广泛筛选,一个非常低的内在的成功率。随机过程和许多蛋白质不因为特定的屈服于结晶它们的分子表面的微观特征。由此可见,理性的表面工程通过定点诱变应该允许系统和显著的改善结晶成功率。建立战略,surface-entropy减少(SER),讨论,包括其成功,局限性和未来可能的发展。

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