Structure of human dual-specificity phosphatase 27 at 2.38 A resolution.

Lountos GT; Tropea JE; Waugh DS

首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Structure of human dual-specificity phosphatase 27 at 2.38 A resolution.

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Structure of human dual-specificity phosphatase 27 at 2.38 A resolution.

机译：人类dual-specificity磷酸酶27的结构2.38一项决议。

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There are over 100 genes in the human genome that encode protein tyrosine phosphatases (PTPs) and approximately 60 of these are classified as dual-specificity phosphatases (DUSPs). Although many dual-specificity phosphatases are still not well characterized, novel functions have been discovered for some of them that have led to new insights into a variety of biological processes and the molecular basis for certain diseases. Indeed, as the functions of DUSPs continue to be elucidated, a growing number of them are emerging as potential therapeutic targets for diseases such as cancer, diabetes and inflammatory disorders. Here, the overexpression, purification and structure determination of DUSP27 at 2.38 A resolution are presented.

机译：有超过100个基因在人类基因组中编码蛋白酪氨酸磷酸酶(中)和这些被列为大约60dual-specificity磷酸酶(DUSPs)。许多dual-specificity磷酸酶仍然没有特点,新颖的功能对于其中的一些发现,导致了新的洞察不同的生物过程和某些疾病的分子基础。事实上,正如DUSPs继续的功能阐明,越来越多的人出现作为疾病的潜在治疗靶点如癌症、糖尿病和炎症障碍。和结构测定DUSP27 2.38提出了解决。

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《Acta crystallographica.Section D. Biological crystallography》 |2011年第5期|471-479|共9页
作者
Lountos GT; Tropea JE; Waugh DS;
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作者单位

Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.;

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原文格式 PDF
正文语种英语
中图分类化学;
关键词
Protein Tyrosine Phosphatases; Human Genome; Dual-Specificity PhosphatasesBiological Process;

机译：蛋白质酪氨酸磷酸酶;人类基因组;Dual-Specificity PhosphatasesBiological过程;

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Structure of human dual-specificity phosphatase 27 at 2.38 A resolution.

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