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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Structure and biochemical characterization of proliferating cellular nuclear antigen from a parasitic protozoon.
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Structure and biochemical characterization of proliferating cellular nuclear antigen from a parasitic protozoon.

机译：的结构和生化特征从一个细胞增殖核抗原寄生原虫。

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摘要

Proliferating cellular nuclear antigen (PCNA) is a toroidal-shaped protein that is involved in cell-cycle control, DNA replication and DNA repair. Parasitic protozoa are early-diverged eukaryotes that are responsible for neglected diseases. In this work, a PCNA from a parasitic protozoon was identified, cloned and biochemically characterized and its crystal structure was determined. Structural and biochemical studies demonstrate that PCNA from Entamoeba histolytica assembles as a homotrimer that is able to interact with and stimulate the activity of a PCNA-interacting peptide-motif protein from E. histolytica, EhDNAligI. The data indicate a conservation of the biochemical mechanisms of PCNA-mediated interactions between metazoa, yeast and parasitic protozoa.
机译：细胞增殖核抗原(PCNA)是一个toroidal-shaped蛋白质参与细胞循环控制、DNA复制和DNA修复。负责被忽视的真核生物疾病。原生动物被发现,克隆生化反应特点及其晶体结构决定。生化研究表明,细胞核抗原痢疾阿米巴homotrimer组装这是能够相互作用和刺激活动的PCNA-interacting peptide-motif蛋白质从大肠阿米巴,EhDNAligI。指示生物的保护PCNA-mediated机制之间的相互作用后生动物、酵母和寄生原生动物。

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