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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Structure of RiVax: a recombinant ricin vaccine.
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Structure of RiVax: a recombinant ricin vaccine.

机译：RiVax结构:重组蓖麻毒素疫苗。

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摘要

RiVax is a recombinant protein that is currently under clinical development as part of a human vaccine to protect against ricin poisoning. RiVax includes ricin A-chain (RTA) residues 1-267 with two intentional amino-acid substitutions, V76M and Y80A, aimed at reducing toxicity. Here, the crystal structure of RiVax was solved to 2.1 A resolution and it was shown that it is superposable with that of the ricin toxin A-chain from Ricinus communis with a root-mean-square deviation of 0.6 A over 258 C(alpha) atoms. The RiVax structure is also compared with the recently determined structure of another potential ricin-vaccine immunogen, RTA 1-33/44-198 R48C/T77C. Finally, the locations and solvent-exposure of two toxin-neutralizing B-cell epitopes were examined and it was found that these epitopes are within or near regions predicted to be involved in catalysis. The results demonstrate the composition of the RiVax clinical material and will guide ongoing protein-engineering strategies to develop improved immunogens.
机译：RiVax是目前的重组蛋白在临床开发作为人类的一部分疫苗来防止蓖麻毒素中毒。包括蓖麻毒蛋白链(RTA)残留1 - 267两个故意氨基酸替换,V76MY80A,旨在减少毒性。晶体结构解决了RiVax 2.1分辨率和显示它superposable与蓖麻毒蛋白毒素链从萝藦均方根偏差为0.6 A / 258 C(α)原子。RiVax结构也比最近确定的另一个结构潜在ricin-vaccine免疫原,等1 - 33/44 - 198 R48C / T77C。solvent-exposure两toxin-neutralizing b细胞抗原表位是研究和发现这些抗原表位内或附近地区预计参与催化。结果表明RiVax的构成临床资料和指导进行蛋白质工程的战略发展

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