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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >The case for an empirical 'high-throughput' neutron scattering approach to protein dynamics.
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The case for an empirical 'high-throughput' neutron scattering approach to protein dynamics.

机译：实证“高通量”的理由中子散射方法蛋白质动力学。

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摘要

Recalling that there are currently more than 63,000 structures deposited in the Protein Data Bank, it is time for neutron scatterers studying protein dynamics to show a similar interest in the diversity that is the basis of biology. Sound experimental data that can underpin and complement molecular-dynamics simulations for fundamental research and health applications such as drug design can and should be provided. A proposal is presented to fulfil the two conditions that are required to enable such an approach: (i) the identification of measurable dynamics parameters that are correlated to biological function and activity and (ii) the design of experiments to measure these parameters efficiently with reasonable throughput.
机译：回忆,目前有超过63000存入蛋白质结构数据银行,是时候让中子散射研究蛋白质动态显示相似的兴趣生物的多样性的基础。能够支撑和实验数据补充的分子动力学模拟基础研究和医疗应用药物设计可以和应该提供。提案提出履行这两个使这样的所需条件方法:(i)可测量的识别相关的动力学参数生物功能和活动,(ii)设计的实验来测量这些参数有效合理的吞吐量。

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