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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Small-angle neutron scattering and contrast variation: a powerful combination for studying biological structures.
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Small-angle neutron scattering and contrast variation: a powerful combination for studying biological structures.

机译：小角中子散射和对比变化:一个强大的组合研究生物结构。

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摘要

The use of small-angle scattering (SAS) in the biological sciences continues to increase, driven as much by the need to study increasingly complex systems that are often resistant to crystallization or are too large for NMR as by the availability of user facilities and advancements in the modelling of biological structures from SAS data. SAS, whether with neutrons (SANS) or X-rays (SAXS), is a structural probe of length scales ranging from 10 to 10,000 A. When applied to biological complexes in dilute solution, it provides size and shape information that can be used to produce structural models that can provide insight into function. SANS enables the use of contrast-variation methods through the unique interaction of neutrons with hydrogen and its isotope deuterium. SANS with contrast variation enables the visualization of components within multisubunit complexes, making it a powerful tool for probing protein-protein and protein-nucleic acid complexes, as well as the interaction of proteins with lipids and detergents.
机译：利用小角散射(SAS)生物科学继续增长,驱动的需要研究的日益复杂系统通常是抵抗为核磁共振结晶或太大了用户设备的可用性进步在生物的造型从SAS数据结构。中子(SANS)或x射线(粉煤灰),是一个结构性的探针的长度尺度从10到10000人当应用于生物大分子在稀释解决方案,它提供了大小和形状的信息可以用于生产结构模型可以提供洞察功能。使contrast-variation方法的使用通过中子的独特交互氢及其同位素氘。支持可视化对比变化组件在multisubunit复合物,使这对探索蛋白质一个强大的工具和protein-nucleic酸复合物,以及脂质和蛋白质之间的相互作用洗涤剂。

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