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首页> 外文期刊>Archiv fur Geflugelkunde >Effect of low dose gamma-radiation upon antioxidant enzymes in chick embryo liver
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Effect of low dose gamma-radiation upon antioxidant enzymes in chick embryo liver

机译：低剂量辐射效应抗氧化酶在小鸡胚胎肝脏

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Exposure of rodents to low-dose whole-body irradiation could cause various antioxidant mechanisms that defend cells from oxidative stress. However, there is a lack of results on antioxidant status in organs of chicken after low dose eggs or whole-bodyirradiation. This study was performed to investigate the effect of low-dose gamma-irradiation upon activity of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and level of glutathione (GSH) and lipid peroxidation (TBARS) in liver of chick embryo and newly hatched chicks. Fertilized chicken eggs were irradiated with the dose of 0.3 Gy gamma radiation (source 60Co) on the 19th day of incubation. The liver samples were taken on 6, 24, 48, 72 and 96 h after egg irradiation. Theantioxidant parameters were measured spectrophotometrically. Level of GSH and lipid peroxidation as well GSH-Px activity increased in the liver of chick embryos on the 6th hour after irradiation. GSH-Px and SOD activity significantly decreased in the liver of chick embryo on the 48 h after egg exposure. Lipid peroxidation level and GSH level also significantly decreased in the liver of chick embryo on the 48 h after egg exposure. CAT activity during the experiment was not statistically different when itcompared to controls. These results suggest that chick embryo exposure to dose of 0.3 Gy gamma-radiation on the 19th day of incubation causes alteration of antioxidant status in chick embryo liver. It also seems, as is the case in mammals, that GSH andGSH-Px could be the first choice in antioxidant defence in chicken embryo liver at early time after low dose irradiation.
机译：接触低剂量全身的啮齿动物辐射可能会导致各种抗氧化剂机制,保护细胞免受氧化压力。抗氧化状态的器官后鸡低剂量鸡蛋或者whole-bodyirradiation。进行调查的影响低剂量辐照的活动谷胱甘肽过氧化物酶(氧化酶),过氧化物歧化酶(SOD)、过氧化氢酶(CAT)和水平谷胱甘肽(GSH)和脂质过氧化(TBARS)小鸡胚胎的肝脏和刚孵出小鸡。0.3 Gyγ辐射剂量(来源60 co) 19天的孵化。采集标本6日、24、48、72和96 h辐照后鸡蛋。测量spectrophotometrically。谷胱甘肽氧化酶和脂质过氧化作用在小鸡胚胎的肝脏活动增加照射后6小时。活动明显降低肝的小鸡胚胎蛋暴露后48 h。脂质过氧化水平,谷胱甘肽水平显著降低肝脏的小鸡胚胎蛋暴露后48 h。在实验中没有活动统计不同itcompared的时候出现控制。接触剂量的0.3 Gy伽马辐射19天的孵化变更的原因在小鸡胚胎肝脏抗氧化状态。看来,在哺乳动物一样,谷胱甘肽andGSH-Px可能是第一选择在鸡胚肝脏抗氧化防御低剂量辐照后早期。

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