Structure of a highly stable mutant of human fibroblast growth factor 1

Anna Szlachcic; Matgorzata Zakrzewska; Daniel Krowarsch

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Structure of a highly stable mutant of human fibroblast growth factor 1

机译：高度稳定的结构变异的人类纤维母细胞生长因子1

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Fibroblast growth factors (FGFs) are involved in diverse cellular processes such as cell migration, angiogenesis, osteo-genesis, wound healing and embryonic and foetal development. Human acidic fibroblast growth factor (FGF-1) is the only member of the FGF family that binds with high affinity to all four FGF receptors and thus is considered to be the human mitogen with the broadest specificity. However, pharmacological applications of FGF-1 are limited owing to its low stability. It has previously been reported that the introduction of single mutations can significantly improve the stability of FGF-1 and its resistance to proteolytic degradation.

机译：纤维母细胞生长因子(fgf)参与不同的细胞过程,如细胞迁移、血管生成、osteo-genesis伤口治疗和胚胎和胎儿的发展。人类酸性成纤维细胞生长因子(FGF-1)唯一的成员FGF结合的家庭所有四个FGF受体,从而高亲和力被认为是人类的有丝分裂原的吗广泛的特异性。的应用由于其FGF-1是有限的较低的稳定。引入单一突变显著改善FGF-1和的稳定性它的抗蛋白水解降解。

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《Acta crystallographica.Section D. Biological crystallography》 |2009年第1期|67-73|共7页
作者
Anna Szlachcic; Matgorzata Zakrzewska; Daniel Krowarsch;
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作者单位

Department of Protein Engineering, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland;

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正文语种英语
中图分类化学;
关键词
FGF1 gene; Fibroblast Growth Factors; Fibroblast Growth Factor 1Cellular processeslarge family;

机译：FGF1基因;成纤维细胞生长因子;成纤维细胞细胞生长因子1 processeslarge家庭;

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Structure of a highly stable mutant of human fibroblast growth factor 1

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