The structure of the BIR3 domain of clAP1 in complex with the N-terminal peptides of SMAC and caspase-9

Ravi raj Kulathila; Brian Vash; David Sage

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The structure of the BIR3 domain of clAP1 in complex with the N-terminal peptides of SMAC and caspase-9

机译：的clAP1 BIR3域的结构复杂的氨基肽的SMAC和caspase-9

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The inhibitor of apoptosis protein (IAP) family of molecules inhibit apoptosis through the suppression of caspase activity. It is known that the XIAP protein regulates both caspase-3 and caspase-9 through direct protein-protein interactions. Specifically, the BIR3 domain of XIAP binds to caspase-9 via a 'hotspot' interaction in which the N-terminal residues of caspase-9 bind in a shallow groove on the surface of XIAP. This interaction is regulated via SMAC, the N-terminus of which binds in the same groove, thus displacing caspase-9.

机译：细胞凋亡蛋白的抑制剂(IAP)的家庭抑制细胞凋亡的分子半胱天冬酶活动的抑制。XIAP蛋白调节caspase-3和caspase-9通过直接蛋白质交互。XIAP结合caspase-9通过一个“热点”交互的氨基端残留caspase-9绑定在一个浅槽表面上XIAP。的n端结合在同一沟,从而取代caspase-9。

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来源
《Acta crystallographica.Section D. Biological crystallography》 |2009年第1期|58-66|共9页
作者
Ravi raj Kulathila; Brian Vash; David Sage;
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作者单位

Novartis Institutes for Biomedical Research Inc., USA;

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原文格式 PDF
正文语种英语
中图分类化学;
关键词
X-Linked Inhibitor of Apoptosis Protein; Caspase 9; CASP9 genegroove faceinhibitor of apoptosis protein;

机译：抑制细胞凋亡蛋白;细胞凋亡蛋白酶9;CASP9 genegroove faceinhibitor细胞凋亡蛋白质;

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1. The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9. [J] . Kulathila R, Vash B, Sage DCornell-Kennon SWright KKoehn JStams TClark KPrice A Acta crystallographica.Section D. Biological crystallography . 2009,第Pta1期

机译：的cIAP1 BIR3域的结构复杂的氨基肽的SMAC和caspase-9。
2. W323S Variant of Xiap–Bir3 Binds to SMAC but not Caspase-9 [J] . Jamshid Davoodi, Azadeh Mohammad-Gholi, Ali Es-haghi, Journal of Biochemistry . 2007,第3期

机译：Xiap–Bir3的W323S变体绑定到SMAC，但不绑定Caspase-9
3. Potent and Selective Small-Molecule Inhibitors ofcIAP1/2 Proteins Reveal That the Binding of Smac Mimetics to XIAPBIR3 Is Not Required for Their Effective Induction of Cell Death inTumor Cells [O] . Haiying Sun, †, Jianfeng Lu, -1

机译：强效和选择性的小分子抑制剂cIAP1 / 2蛋白揭示了Smac模拟物与XIAP的结合BIR3不需要有效诱导细胞死亡肿瘤细胞
4. Smac-derived Aza-peptide As an Aminopeptidase-resistant XIAP BIR3 Antagonist [O] . Elsawy, Mohamed A., Tikhonova, Irina G., Martin, Lorraine, 2015

机译：Smac衍生的氮杂肽作为抗氨肽酶的XIAP BIR3拮抗剂
5. Deinococcus Mn2+ -Peptide Complex: A Novel Approach to Alphavirus Vaccine Development. [R] . Gayen, M., Glass, P. J., Gupta, P., 2016

机译：Deinococcus mn2 + -peptide Complex：一种新的甲病毒疫苗开发方法。

The structure of the BIR3 domain of clAP1 in complex with the N-terminal peptides of SMAC and caspase-9

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