Structure of NS1A effector domain from the influenza A/Udorn/72 virus

Shuangluo Xia; Arthur F. Monzingo; Jon D. Robertus

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Structure of NS1A effector domain from the influenza A/Udorn/72 virus

机译：NS1A结构效应的域甲型流感病毒/ Udorn / 72

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The nonstructural protein NS1A from influenza virus is a multifunctional virulence factor and a potent inhibitor of host immunity. It has two functional domains: an N-terminal 73-amino-acid RNA-binding domain and a C-terminal effector domain. Here, the crystallographic structure of the NS1A effector domain of influenza A/Udorn/72 virus is presented. Structure comparison with the NS1 effector domain from mouse-adapted influenza A/Puerto Rico/8/34 (PR8) virus strain reveals a similar monomer conformation but a different dimer interface. Further analysis and evaluation shows that the dimer interface observed in the structure of the PR8 NS1 effector domain is likely to be a crystallographic packing effect. A hypothetical model of the intact NS1 dimer is presented.

机译：非结构蛋白NS1A流感病毒是一种多功能和毒力因子宿主免疫力的有效抑制剂。功能域:一个氨基端73 -胺基酸rna结合域和c端效应域。甲型流感的NS1A效应领域/ Udorn / 72病毒。NS1效应域mouse-adapted流感/波多黎各/ 8/34 (PR8)揭示了一个病毒株类似的单体构象不同二聚体界面。显示二聚体界面中观察到PR8 NS1效应的结构域可能是晶体包装效果。完整的NS1二聚体的假设模型提出了。

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来源
《Acta crystallographica.Section D. Biological crystallography》 |2009年第1期|11-17|共7页
作者
Shuangluo Xia; Arthur F. Monzingo; Jon D. Robertus;
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作者单位

Institute for Cellular and Molecular Biology, Department of Chemistry and Biochemistry, University of Texas, 1 University Station A5300, Austin, TX 78712, USA;

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原文格式 PDF
正文语种英语
中图分类化学;
关键词
Dimers; Virulence Factors; influenzaDomainNonstructural proteinsInfluenza VirusCrystallization;

机译：二聚体;毒性因素;influenzaDomainNonstructuralproteinsInfluenza VirusCrystallization;

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4. Structure of NS1A effector domain from the influenza A/Udorn/72 virus. [J] . Xia S, Monzingo AF, Robertus JD Acta crystallographica.Section D. Biological crystallography . 2009,第Pta1期

机译：NS1A结构效应的域甲型流感病毒/ Udorn / 72。
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机译：Sodium ferulate protects against influenza virus infection by activation of the TLR7/9-MyD88-IRF7 signaling pathway and inhibition of the ^z>NF-kB signaling pathwayYanhui Zhu a, Yong Shao, Xinyan Qu, Jing Guo, Jing Yang, Zhe Zhou, Shengqi Wang
6. Structure of NS1A effector domain from the influenza A/Udorn/72 virus [O] . Shuangluo Xia, Arthur F. Monzingo, Jon D. Robertus -1

机译：甲型流感病毒/ Udorn / 72病毒的NS1A效应子结构域
7. Structure of NS1A effector domain from the influenza A/Udorn/72 virus [O] . Xia, Shuangluo, Monzingo, Arthur F., Robertus, Jon D. 2008

机译：甲型流感病毒/ Udorn / 72病毒的NS1A效应子结构域

Structure of NS1A effector domain from the influenza A/Udorn/72 virus

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