Structure of the X (ADRP) domain of nsp3 from feline coronavirus

WojdylaJ.A.; ManolaridisI.; SnijderE.J.GorbalenyaA.E.CoutardB.PiotrowskiY.HilgenfeldR.TuckerP.A.

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Structure of the X (ADRP) domain of nsp3 from feline coronavirus

机译：结构的X (ADRP)域nsp3的猫科动物冠状病毒

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The structure of the X (or ADRP) domain of a pathogenic variant of feline coronavirus (FCoV) has been determined in tetragonal and cubic crystal forms to 3.1 and 2.2 ? resolution, respectively. In the tetragonal crystal form, glycerol-3-phos-phate was observed in the ADP-ribose-binding site. Both crystal forms contained large solvent channels and had a solvent content of higher than 70%. Only very weak binding of this domain to ADP-ribose was detected in vitro. However, the structure with ADP-ribose bound was determined in the cubic crystal form at 3.9 ? resolution. The structure of the FCoV X domain had the expected macro-domain fold and is the first structure of this domain from a coronavirus belonging to subgroup 1a.

机译：X(或ADRP)的结构域致病变种的猫科动物冠状病毒(FCoV)已经决定在正方和立方吗3.1和2.2晶体形式?分别。glycerol-3-phos-phate被观察到的ADP-ribose-binding网站。含有大量溶剂,渠道溶剂的含量高于70%。弱结合这一领域ADP-ribose检测到体外。ADP-ribose绑定立方的决心在3.9晶体形式吗?FCoV X域的预期宏领域褶皱,是第一个结构从冠状病毒属于这一领域1组。

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《Acta crystallographica.Section D. Biological crystallography》 |2009年第12期|1292-1300|共9页
作者
WojdylaJ.A.; ManolaridisI.; SnijderE.J.GorbalenyaA.E.CoutardB.PiotrowskiY.HilgenfeldR.TuckerP.A.;
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作者单位

EMBL Hamburg Outstation, C/o DESY, Notkestrasse 85, D-22603 Hamburg, Germany;

Laboratoire Architecture et Fonction des Macromolécules Biologiques, UMR 6098, AFMB-CNRS-ESIL, 163;

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical CenterInstitute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck;

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正文语种英语
中图分类化学;
关键词
nonstructural protein 3; Feline Coronavirus; Domaincrystal outlineCOPPER ALLOY NO 757Adenosine Diphosphate Ribose;

机译：非结构蛋白3;猫冠状病毒;Domaincrystal outlineCOPPER合金757年腺苷二磷酸核糖;

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Structure of the X (ADRP) domain of nsp3 from feline coronavirus

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