Structure of the G225P/G226P mutant of mouse 3(17)a-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate

Urmi Dhagat; Satoshi Endo; Hiroaki Mamiya

首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Structure of the G225P/G226P mutant of mouse 3(17)a-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate

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Structure of the G225P/G226P mutant of mouse 3(17)a-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate

机译：G225P / G226P结构突变的老鼠3 (17) a-hydroxysteroid脱氢酶(AKR1C21)三元复杂:绑定的影响抑制剂和底物

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3(17)a-Hydroxysteroid dehydrogenase (AKR1C21) is a unique member of the aldo-keto reductase (AKR) superfamily owing to its ability to reduce 17-ketosteroids to 17a-hydroxysteroids, as opposed to other members of the AKR family, which can only produce 17beta-hydroxysteroids. In this paper, the crystal structure of a double mutant (G225P/G226P) of AKR1C21 in complex with the coenzyme NADP+ and the inhibitor hexoestrol refined at 2.1 A resolution is presented.

机译：3 (17) a-Hydroxysteroid脱氢酶(AKR1C21)唯一的元素aldo-keto还原酶(AKR)总科由于其减少的能力17-ketosteroids 17 a-hydroxysteroids,反对AKR家族的其他成员只能生产17 beta-hydroxysteroids。纸,双突变体的晶体结构(G225P / G226P) AKR1C21复杂的辅酶NADP +和抑制剂hexoestrol精制为2.1一项决议。

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《Acta crystallographica.Section D. Biological crystallography》 |2009年第3期|257-265|共9页
作者
Urmi Dhagat; Satoshi Endo; Hiroaki Mamiya;
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作者单位

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia;

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原文格式 PDF
正文语种英语
中图分类化学;
关键词
17-Ketosteroids; carbonyl reductase (NADPH); MutantsTernarycrystal structureDehydrogenases;

机译：17-Ketosteroids;羰基还原酶structureDehydrogenases;

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1. Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate. [J] . Dhagat U, Endo S, Mamiya HHara AEl-Kabbani O Acta crystallographica.Section D. Biological crystallography . 2009,第Pta3期

机译：G225P / G226P结构突变的老鼠3 (17) alpha-hydroxysteroid脱氢酶(AKR1C21)三元复杂:绑定的影响抑制剂和底物。
2. The crystal structure of phosphoglucose isomerase/autocrine motility factor/neuroleukin complexed with its carbohydrate phosphate inhibitors suggests its substrate/receptor recognition [O] . Chou, C.C., Sun, Y.J., Meng, M.S., 2014

机译：The crystal structure of phosphoglucose isomerase/autocrine motility factor/neuroleukin complexed with its carbohydrate phosphate inhibitors suggests its substrate/receptor recognition

Structure of the G225P/G226P mutant of mouse 3(17)a-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate

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