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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Model-building strategies for low-resolution X-ray crystallographic data.
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Model-building strategies for low-resolution X-ray crystallographic data.

机译：对低分辨率x射线模型策略晶体数据。

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摘要

The interpretation of low-resolution X-ray crystallographic data proves to be challenging even for the most experienced crystallographer. Ambiguity in the electron-density map makes main-chain tracing and side-chain assignment difficult. However, the number of structures solved at resolutions poorer than 3.5 A is growing rapidly and the structures are often of high biological interest and importance. Here, the challenges faced in electron-density interpretation, the strategies that have been employed to overcome them and developments to automate the process are reviewed. The methods employed in model generation from electron microscopy, which share many of the same challenges in providing high-confidence models of macromolecular structures and assemblies, are also considered.
机译：低分辨率的x射线的解释晶体数据证明是一个挑战即使是最有经验的晶体。模棱两可的电子密度图主链和侧链跟踪任务困难。在决议解决贫穷比3.5通常的快速增长和结构高生物兴趣和重要性。电子密度的所面临的挑战解释的策略用来克服这些障碍和发展自动化的过程进行了综述。用于从电子模型生成显微镜,共享许多相同的在提供高信任度模型的挑战大分子结构和组件也会考虑。

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