Sequence alignment for molecular replacement.

Barton GJ

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Sequence alignment for molecular replacement.

机译：序列比对分子替换。

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This article focuses on the key step of obtaining the best possible sequence alignment of the Query (the protein you are interested in) to the Target (a protein of known three-dimensional structure) in order to build a molecular model for molecular replacement. Common sequence-alignment methods are discussed, starting from structural alignment and then moving to pairwise, multiple and profile-profile methods. The limitations of sequence-alignment methods and guidelines on how to judge the likely accuracy of alignment are considered. This is not a detailed tutorial on how to use specific programs; rather, the reader is directed to current tools and techniques that are likely to yield good results.

机译：本文主要讨论获得的关键一步最好的序列比对查询的(你感兴趣的蛋白质)的目标(已知三维结构的蛋白质)为了建立一个分子的分子模型更换。进行了讨论,从结构调整然后搬到成对,多个和profile-profile方法。序列比对方法和如何指导方针判断可能的对准精度考虑。如何使用特定的程序;针对当前的工具和技术可能会产生好的结果。

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来源
《Acta crystallographica.Section D. Biological crystallography》 |2008年第1期|25-32|共8页
作者
Barton GJ;
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作者单位

School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland. geoff@compbio.dundee.ac.uk;

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原文格式 PDF
正文语种英语
中图分类化学;
关键词
Bioinformatics; Sequence Alignment; DatabaseAmino Acid SequenceProteinmolecular modelAlignmentcoplaningComputational Biology;

机译：生物信息学,序列比对;DatabaseAmino酸SequenceProteinmolecularmodelAlignmentcoplaningComputational生物学;

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Sequence alignment for molecular replacement.

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