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BALBES: a molecular-replacement pipeline

机译:BALBES: molecular-replacement管道

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摘要

The number of macromolecular structures solved and deposited in the Protein Data Bank (PDB) is higher than 40 000. Using this information in macromolecular crystallography (MX) should in principle increase the efficiency of MX structure solution. This paper describes a molecular-replacement pipeline, BALBES, that makes extensive use of this repository. It uses a reorganized database taken from the PDB with multimeric as well as domain organization. A system manager written in Python controls the workflow of the process. Testing the current version of the pipeline using entries from the PDB has shown that this approach has huge potential and that around 75% of structures can be solved automatically without user intervention.
机译:大分子结构的数量和解决沉积在蛋白质数据库(PDB)高于40 000。大分子晶体学(MX)增加MX结构的效率原则解决方案。BALBES molecular-replacement管道,大量使用这个库。重组数据库从PDBmultimeric以及域组织。系统经理用Python编写的控制工作流的过程。版本的管道使用的条目PDB表明这种方法有巨大的潜力和大约75%的结构无需用户自动得到解决干预。

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