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首页> 外文期刊>Archives of Neurology >The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period.
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The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period.

机译：载脂蛋白Eε4等位基因和下降在六年期间不同的认知系统时期。

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CONTEXT: Impairment of episodic memory is an early and defining feature of Alzheimer disease (AD). The apolipoprotein E (APOE) epsilon 4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic memory differently from other cognitive functions. OBJECTIVE: To examine the association of epsilon 4 with decline in different cognitive systems. DESIGN: Longitudinal cohort study. SETTING: More than 40 groups of Catholic clergy from across the United States. PARTICIPANTS: Older Catholic clergy members without clinical evidence of dementia at baseline underwent annual clinical evaluations for up to 6 years. Of 624 persons eligible for follow-up, 611 (98%) participated, of whom 161 (26%) had at least 1 epsilon 4 allele. They completed an average of 5.5 evaluations (range, 2-7). MAIN OUTCOME MEASURES: Incident AD and annual rates of change in episodic memory, semantic memory, working memory, perceptual speed, and visuospatial ability. RESULTS: The presence of epsilon 4 was associated with risk of developing AD on follow-up (relative risk, 1.92; 95% confidence interval, 1.27-2.89). In a series of random effects models, epsilon 4 was associated with impaired baseline function in episodic memory and visuospatial ability and with more rapid decline in all domains. The effect of epsilon 4 on annual decline in episodic memory (>3-fold increase) was significantly stronger than its effect on decline in other cognitive systems (P<.01), and at baseline, its effect on episodic memory was marginally stronger than its effect on other cognitive domains (P =.06). CONCLUSION: The results suggest that the APOE epsilon 4 allele influences risk of AD by a relatively selective effect on episodic memory.
机译：背景:情景记忆是早期的损伤阿尔茨海默病(AD)和定义的特性。载脂蛋白E (APOE)ε4等位基因已知影响广告的风险,但它已经很难确定它影响情景记忆与其他认知不同功能。不同的认知下降的ε4系统。设置:40多个组的天主教神职人员来自美国。老人没有临床天主教神职人员痴呆在基线进行了年度的证据6年的临床评估。人资格获得随访,611例(98%)参加,其中有161(26%)至少有1ε4等位基因。5.5评估(范围2 - 7日)。措施:事件的广告和年度利率的变化在情景记忆、语义记忆、工作记忆、知觉速度和视觉空间的能力。与风险相关的广告后续(相对风险,1.92;区间,1.27 - -2.89)。效应模型,ε4是相关联的受损的基线情景记忆和函数视觉空间的能力和更多的快速下降在所有的领域。情景记忆下降(三倍增加>)明显强于其效果下降在其他认知系统(P < . 01),而在基线,它对情景记忆的影响对其他略强于其影响认知领域(P = 0。06)。结果表明,APOEε4等位基因影响广告的风险相对选择性对情景记忆的影响。

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