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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction.
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Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction.

机译：测量的复合物的形成酪氨酸kinase-mediated信号转导。

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摘要

Isothermal titration calorimetry (ITC) provides highly complementary data to high-resolution structural detail. An overview of the methodology of the technique is provided. Ultimately, the correlation of the thermodynamic parameters determined by ITC with structural perturbation observed on going from the free to the bound state should be possible at an atomic level. Currently, thermodynamic data provide some insight as to potential changes occurring on complex formation. Here, this is demonstrated in the context of in vitro quantification of intracellular tyrosine kinase-mediated signal transduction and the issue of specificity of the important interactions. The apparent lack of specificity in the interactions of domains of proteins involved in early signalling from membrane-bound receptors is demonstrated using data from ITC.
机译：等温滴定量热法(ITC)提供高度互补的高分辨率数据结构的细节。提供的技术。相关的热力学参数由ITC结构摄动观察从自由到绑定在原子级别状态应该是可能的。目前,热力学提供了一些数据了解潜在的变化发生复杂的形成。体外的量化的上下文细胞内酪氨酸kinase-mediated信号转导和特异性的问题重要的交互。特异性的相互作用域的蛋白质参与的早期信号膜结合受体演示使用ITC的数据。

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