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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Structure of the response regulator VicR DNA-binding domain
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Structure of the response regulator VicR DNA-binding domain

机译：监管机构VicR结构的响应dna结合域

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摘要

The response regulator VicR from the Gram-positive bacterium Enterococcus faecalis forms part of the two-component signal transduction system of the YycFG subfamily. The structure of the DNA-binding domain of VicR, VicRc, has been solved and belongs to the winged helix-turn-helix family. It is very similar to the DNA-binding domains of Escherichia coli PhoB and OmpR, despite low sequence similarity, but differs in two important loops. The alpha-loop, which links the two helices of the helix-turn-helix motif, is similar to that of PhoB, where it has been implicated in contacting the sigma subunit of RNA polymerase, but differs from that of OmpR. Conversely, the loop following the helix-turn-helix motif is similar to that of OmpR and differs from that of PhoB. YycF/VicR, PhoB and Bacillus subtilis PhoP regulators all recognize almost identical DNA sequences and although there is currently no experimental evidence linking this loop with the DNA, the structure is consistent with possible involvement in selective DNA recognition or binding.
机译：响应调节器VicR革兰氏阳性粪肠球菌细菌形式的一部分双组分信号转导系统的YycFG亚科。VicRc VicR领域,已经解决了属于翼helix-turn-helix家庭。非常类似于dna结合域的大肠杆菌PhoB OmpR,尽管低序列相似性,但在两个重要的不同循环。螺旋helix-turn-helix图案,是相似的PhoB,都会涉及到联系RNA聚合酶的σ亚基,但不同于OmpR。后循环helix-turn-helix主题OmpR相似和不同PhoB。监管机构都承认几乎相同的DNA序列,尽管目前还没有实验证据表明这个循环DNA的结构是一致的参与DNA识别或选择性绑定。

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