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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Packing and loop-structure variations in non-isomorphous crystals of FabZ from Plasmodium falciparum
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Packing and loop-structure variations in non-isomorphous crystals of FabZ from Plasmodium falciparum

机译：包装和循环结构的变化non-isomorphous晶体的FabZ疟原虫恶性疟原虫

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摘要

The crystals obtained from various batches of crystallization trials of FabZ from Plasmodium falciparum exhibited non-isomorphism. The c axis of the I222 cell showed a large variation of about 16 A, from c = 81 angstrom to c = 97 angstrom. Complete data sets were collected for three crystal forms with varying lengths of the c axis (form 1, c = 97 angstrom form 2, c = 92 angstrom form 3, c = 81 angstrom). The crystal structure of form 1 has been reported previously. Here, the crystal structures of the other two crystal forms are reported and a detailed structural comparison is made of the three crystal forms in order to explore the possible reasons for the existence of non-isomorphism. The conformations of three loops vary between the three crystal forms. The disposition of the loops affects the crystal packing and hence the unit-cell parameter. The crystallization condition and crystallization method employed, which change the evaporation rate, determine the crystal form of the enzyme. The present analysis shows that pH-induced intrinsic conformational changes in the protein play a key role in the observed differences.
机译：不同批次的获得的晶体结晶试验FabZ疟原虫恶性疟原虫non-isomorphism展出。I222细胞显示一个大的变化从c约16 A, c = 97 = 81埃埃。三个水晶形式与不同长度的c轴(表格1 c = 97埃的形式2 c = 92埃形式3 c = 81埃)。1据报道之前的结构形式。在这里,其他两个的晶体结构晶体形式报告和详细是由三个结构比较为了探索可能的晶体形式non-isomorphism的存在的理由。构象的三个循环之间的不同三个水晶形式。影响的水晶包装,因此晶胞参数。条件和采用结晶方法,改变蒸发率,确定吗晶体形式的酶。表明pH-induced内在的构象蛋白质的变化起着关键的作用观察到的差异。

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