Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.

Day P; Sharff A; Parra LCleasby AWilliams MHorer SNar HRedemann NTickle IYon J

首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.

【24h】

Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.

机译：一双CBS-domain的监管结构人类与AMP AMPK在复杂的γ亚基

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

AMP-activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine beta-synthase) domains in the regulatory gamma subunit. The structure of a CBS-domain pair from human AMPK gamma1 in complex with the physiological activator AMP and the pharmacological activator ZMP (AICAR) is presented.

机译：活化激酶(AMPK)是核心传感通过绑定的真核细胞能量状态AMP和ATP CBS(胱硫醚beta-synthase)域名监管γ亚基。一双CBS-domain从人类AMPK的结构γ在复杂的生理活化剂AMP和药理活化剂ZMP(爱卡)。

著录项

来源
《Acta crystallographica.Section D. Biological crystallography》 |2007年第5期|587-596|共10页
作者
Day P; Sharff A; Parra LCleasby AWilliams MHorer SNar HRedemann NTickle IYon J;
展开▼
作者单位

Astex Therapeutics Ltd, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, England. p.day@astex-therapeutics.com;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类化学;
关键词
AMP-Activated Protein Kinases; Adenylate Kinase; RibonucleotidesAminoimidazole Carboxamide;

机译：腺苷酸活化蛋白激酶激酶;RibonucleotidesAminoimidazole甲酰胺;

相似文献

外文文献
中文文献

1. An Analysis-of-Variance (ANOVA) Approach for Sib-pair Linkage Analysis of Complex Ordinal Human Diseases [J] . KATHYL.Moser, ERICJ.Topol 中国生物医学工程学报：英文版 . 2002,第003期
2. Dual Characteristic Pairs in Generalized Complex Structures [J] . YIN Yan-bin, LIU Ling, LIU Hua-qiao 数学季刊（英文版） . 2013,第002期
3. Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. [J] . Adams J, Chen ZP, Van Denderen BJ, Protein Science: A Publication of the Protein Society . 2004,第1期

机译：通过gamma1亚基AMP变构调节位点进行AMPK的空间控制。

Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.

摘要

著录项

相似文献

相关主题

期刊订阅