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首页> 外文期刊>Archives of Neurology >Intracranial volume and Alzheimer disease: evidence against the cerebral reserve hypothesis.
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Intracranial volume and Alzheimer disease: evidence against the cerebral reserve hypothesis.

机译：颅内体积和阿尔茨海默病:证据对脑储备假说。

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BACKGROUND: Total intracranial volume (TIV) measurement commonly is used to correct for variations in premorbid brain size in imaging studies of cerebral structures in Alzheimer disease (AD). This assumes no intrinsic difference in TIV between patients and control subjects and that TIV measurements are unaffected by cerebral atrophy. However, an autopsy study has suggested that a larger premorbid brain may protect against AD onset. A recent computed tomographic study lent support to this by finding a correlation between intracranial size and age at onset of AD in women. OBJECTIVE: To investigate the relationship between TIV and sporadic and familial AD. DESIGN: Retrospective case study. SETTING: Specialist dementia clinic. PATIENTS: Eighty-five patients with AD and 52 healthy volunteers. MAIN OUTCOME MEASURES: Age at symptom onset and TIV measured using a semiautomatic interactive thresholding technique on magnetic resonance imaging spanning the entire intracranial cavity. RESULTS: Reproducibility measurement was high (intrarater coefficient of variation, 1.2%; interrater coefficient of variation, 0.7%). Unlike brain atrophy in the patients with AD, TIV did not vary over time. Mean TIV did not differ significantly between any of the subject groups. There was no association between TIV and age or age at symptom onset. The only significant predictor of TIV was sex. CONCLUSIONS: Measurements of TIV are independent of atrophy and can be used safely to adjust for differences in head size in studies of cerebral structure in AD. Premorbid brain size does not differ between patients with familial and sporadic AD and controls and does not delay disease onset.
机译：背景:颅内总额(TIV)测量一般用于纠正成像在发病前大脑尺寸的变化脑结构的研究在老年痴呆症病(AD)。之间的差异TIV病人和控制主题和TIV测量不受影响脑萎缩。建议一个更大的发病前的大脑可能吗防止AD发病。层析研究支持这个发现颅内的大小和年龄之间的关系在女性出现广告。调查TIV和之间的关系零星的和家庭的广告。案例研究。病人:八十五AD患者和52健康的志愿者。症状出现和TIV测量使用半自动交互式阈值技术在磁共振成像生成整个颅内腔。测量高(intrarater系数变异,1.2%;变异,0.7%)。广告,患者TIV不随时间变化。意味着TIV之间没有显著差异主题的团体。TIV和年龄和年龄之间的症状出现。只有重要的预测TIV性。结论:测量TIV是独立的萎缩的调整,可以安全使用头的大小差异对大脑的研究结构的广告。不同家庭和患者之间零星的广告和控制,不拖延疾病发作。

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