...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Structures of complexes between echinomycin and duplex DNA
【24h】

Structures of complexes between echinomycin and duplex DNA

机译：结构echinomycin和之间的配合物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The structure of the bis-intercalation complex of the depsipeptide antibiotic echinomycin with (CGTACG)(2) has been redetermined at a higher resolution (1.4 angstrom) and new high-resolution structures (1.1-1.5 angstrom) are reported for the complexes of echinomycin with (GCGTACGC)(2) (at both low and high ionic strengths) and (ACGTACGT)(2). The structures show the expected Hoogsteen pairing for the base pairs flanking the intercalating chromophores on the outside and Watson-Crick pairing for both base pairs enclosed by the echinomycin. In the octamer complexes but not the hexamer complex, the echinomycin molecule, which would possess a molecular twofold axis were it not for the thioacetal bridge, shows twofold disorder. In all the structures the stacking of the base pairs and chromophores is extended by intermolecular stacking. The structures provide more precise details of the hydrogen bonding and other interactions between the bis-intercalating antibiotics and the duplex DNA than were previously available.
机译：bis-intercalation复杂的结构depsipeptide抗生素echinomycin(CGTACG)(2)一直再决定在更高分辨率(1.4埃)和新的高分辨率结构(1.1 - -1.5埃)报告echinomycin的复合物(GCGTACGC) (2)(在低和高离子强度)(ACGTACGT)(2)。Hoogsteen配对的碱基对的侧面再发色团在外面沃森克里克碱基对封闭的配对echinomycin。不是六聚物复杂,echinomycin分子,具有分子双重的轴要不是thioacetal桥,节目两方面的障碍。堆积的碱基对和发色团延长分子间堆积。结构提供更精确的细节氢键等相互作用bis-intercalating抗生素和双工比以前可用的DNA。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号