Evidence for the induction of a tumour associated cell surface protease on cytologically normal epithelial cells present in the sputum of patients possessing lung tumours.

Steven FS; Katsumi T; Payne PW; Denton J

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Evidence for the induction of a tumour associated cell surface protease on cytologically normal epithelial cells present in the sputum of patients possessing lung tumours.

机译：在患有肺肿瘤的患者的痰中存在的细胞学上正常的上皮细胞上诱导肿瘤相关细胞表面蛋白酶的证据。

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Sputum obtained from healthy subjects and patients with known lung tumours has been challenged with fluorescent probes for the presence of an active cell surface protease. The mature epithelial cells from healthy patients' sputum lacked ability to bind these fluorescent probes whilst the majority of mature epithelial cells in the tumour patients' sputum bound these probes and consequently fluoresced. This demonstrable difference in the cell surface chemistry of mature epithelial cells was linked to the presence of lung tumour cells, which also possessed this cell surface protease. The mechanism of this induced cell surface enzyme appearance is not understood.

机译：从健康受试者和患有已知肺肿瘤的患者获得的痰液已经用荧光探针挑战了是否存在活性细胞表面蛋白酶。健康患者痰液中的成熟上皮细胞缺乏结合这些荧光探针的能力，而肿瘤患者痰液中的大多数成熟上皮细胞结合了这些探针，因此发出了荧光。成熟的上皮细胞在细胞表面化学上的这种明显差异与肺肿瘤细胞的存在有关，肺肿瘤细胞也拥有这种细胞表面蛋白酶。这种诱导的细胞表面酶出现的机制尚不清楚。

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《Anticancer Research: International Journal of Cancer Research and Treatment》 |1999年第4c期|共3页
作者
Steven FS; Katsumi T; Payne PW; Denton J;
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正文语种 eng
中图分类肿瘤学;
关键词
Carboxylic Ester Hydrolases; Endopeptidases biosynthesis; Lung Neoplasms; 羧酸酯水解酶类; 肺肿瘤; 痰;

机译：Carboxylic Ester Hydrolases;Endopeptidases biosynthesis;Lung Neoplasms;羧酸酯水解酶类;肺肿瘤;痰;

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专利

1. Evidence for the induction of a tumour associated cell surface protease on cytologically normal epithelial cells present in the sputum of patients possessing lung tumours. [J] . Steven FS, Katsumi T, Payne PW, Anticancer Research: International Journal of Cancer Research and Treatment . 1999,第4C期

机译：在患有肺肿瘤的患者的痰中存在的细胞学上正常的上皮细胞上诱导肿瘤相关细胞表面蛋白酶的证据。
2. Differential regulation of protease and extracellular matrix protein expression by transforming growth factor-beta 1 in non-small cell lung cancer cells and normal human bronchial epithelial cells [J] . Sonia B. Jakowlew, Jennifer M. Mariano, Liang You, Biochimica et biophysica acta. Gene structure and expression . 1997,第2期

机译：通过转化生长因子-β1在非小细胞肺癌细胞和正常人支气管上皮细胞中对蛋白酶和细胞外基质蛋白表达的差异调节
3. Morphological analysis of circulating tumour cells in patients undergoing surgery for non-small cell lung carcinoma using the isolation by size of epithelial tumour cell (ISET) method. [J] . V Hofman, E Long, M Ilie, Cytopathology . 2012,第1期

机译：使用上皮肿瘤细胞大小（ISET）分离技术对非小细胞肺癌手术患者循环肿瘤细胞的形态学分析。
4. Detection and summation of pus cells and epithelial cells for sputum quality grading using K-Means clustering and color thresholding [C] . Halim Norazura Abd., Hamid Rosyati, Mohamed Zeehaida, 2012 7th International Conference on Computing and Convergence Technology . 2012

机译：使用K-Means聚类和颜色阈值检测和总结脓细胞和上皮细胞的痰液质量分级
5. The effect of iron-containing particulates on induction and activity of the transcription factors nuclear factor κB, early growth response 1, and activating transcription factor 3 in human lung epithelial cells [D] . Buelow, Laura Cecile 2007

机译：含铁颗粒物对人肺上皮细胞转录因子核因子κB的诱导和活性，早期生长反应1和活化转录因子3的影响
6. Cell-mediated immune responses to syngeneic ultraviolet-induced tumours. V. Assessment of accessory and antigen-presenting cell capabilities of normal and ultraviolet-irradiated mice in the generation of anti-tumour cytotoxic effector cells in vitro. [O] . D H Lynch, M F Gurish, R A Daynes 1982

机译：细胞对同基因紫外线诱导的肿瘤的免疫应答。 V.评估正常和紫外线照射的小鼠在体外产生抗肿瘤细胞毒性效应细胞的辅助和抗原呈递细胞的能力。
7. Sputum cytology of squamous cell carcinoma in situ of lung-Morphologic companisation with atypical cells from patients without cancer- [O] . Mikako SATO, Kazutoshi NIHEI, Seiko CHIBA, 2005

机译：鳞状细胞癌的肺形态伴肺形态伴患者肺形态伴患者的痰细胞学细胞学 -
8. Sulfur Mustard Induces Apoptosis in Cultured Normal Human Airway Epithelial Cells: Evidence of a Dominant Caspase-8-Mediated Pathway and Differential Cellular Responses [R] . Ray, R., Keyser, B., Benton, B., 2008

机译：硫芥诱导培养的正常人呼吸道上皮细胞凋亡：Caspase-8介导的主要途径和差异细胞反应的证据

Evidence for the induction of a tumour associated cell surface protease on cytologically normal epithelial cells present in the sputum of patients possessing lung tumours.

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