Structure of the uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans

Leiros I; Moe E; Smalas AOMcSweeney S

首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Structure of the uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans

【24h】

Structure of the uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans

机译：结构的uracil-DNA N-glycosylase ())从耐辐射球菌

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Uracil-DNA glycosylases are DNA-repair enzymes that catalyse the removal of promutagenic uracil from single- and double-stranded DNA, thereby initiating the base-excision repair (BER) pathway. Uracil in DNA can occur by mis-incorporation of dUMP in place of dTMP during DNA synthesis or by deamination of cytosine, resulting in U - A or U - G mispairs. The radiation-resistant bacterium Deinococcus radiodurans has an elevated number of uracil-DNA glycosylases compared with most other organisms. The crystal structure of dr0689 (uracil-DNA N-glycosylase), which has been shown to be the major contributor to the removal of mis-incorporated uracil bases in crude cell extracts of D. radiodurans, is reported.

机译：Uracil-DNA dna修复酶糖基化酶催化去除promutagenic尿嘧啶从单-和双链DNA,从而启动base-excision修复(BER)途径。期间dTMP mis-incorporation转储的地方DNA合成或由胞嘧啶脱氨基作用导致U - A或U - G mispairs。防辐射的细菌耐放射耐辐射奇球菌有高架uracil-DNA的数量糖基化酶与其他生物。的晶体结构dr0689 (uracil-DNAN-glycosylase),它已被证明的去除的主要因素在原油细胞mis-incorporated尿嘧啶基地耐辐射奇球菌的质粒提取的报道。

著录项

来源
《Acta crystallographica.Section D. Biological crystallography》 |2005年第8期|1049-1056|共8页
作者
Leiros I; Moe E; Smalas AOMcSweeney S;
展开▼
作者单位

European Synchrotron Radiat Facil, F-38043 Grenoble, France;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类化学;
关键词
DNA Repair; crystal structure; PurificationUracilDeinococcus radioduransSpecificityfunctional/structural genomics2'-deoxyuridylic acidGadus morhuaRefiningmutational analysis;

机译：晶体DNA修复;结构;PurificationUracilDeinococcusradioduransSpecificityfunctional /结构genomics2”-deoxyuridylic acidGadusmorhuaRefiningmutational分析;

相似文献

外文文献
中文文献
专利

1. Chromium (Ⅲ) Biosorption of Deinococcus radiodurans and Its Vitreoscilla Haemoglobin (vgb) Gene-Transferred Recombinants [J] . Elif Ozbey, Dilek Asma 药剂与药理学：英文版 . 2021,第004期
2. Separation of Recombinant Geranylgeranyl Diphosphate Synthase of Deinococcus radiodurans from Expressed Strain Cell Homogenate by Immobilized Metal Affinity Chromatography on a Characterized Monolithic Cryogel Column [J] . SHEN Shaochuan, WANG Liangyan, SUN Zongtao, 中国化学工程学报（英文版） . 2013,第006期
3. Cooperation of PprI and DrRRA in response to extreme ionizing radiation in Deinococcus radiodurans [J] . WANG LiangYan, YIN LongFei, XU GuangZhi, 中国科学通报：英文版 . 2012,第001期
4. Deinococcus radiodurans Deinococcus radiodurans DR1088 is a novel RecF‐interacting protein that stimulates single‐stranded DNA annealing [J] . Cheng Kaiying, Xu Guangzhi, Xu Hong, Molecular Microbiology . 2017,第4期

机译：Deinococcus radiodurans Deinococcus radiodurans DR1088是一种新型RECF - 相互作用蛋白，刺激单链DNA退火
5. Structural and biophysical analysis of interactions between cod and human uracil-DNA N-glycosylase (UNG) and UNG inhibitor (Ugi) [J] . Assefa Netsanet Gizaw, Niiranen Laila, Johnson Kenneth A.Leiros Hanna-Kirsti SchroderSmalas Arne OskarWillassen Nils PederMoe Elin Acta crystallographica.Section D. Biological crystallography . 2014,第8期

机译：结构和生物物理分析鳕鱼和人类uracil-DNA之间的相互作用N-glycosylase())和)抑制剂(Ugi)
6. Thermal unfolding studies of cold adapted uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). A comparative study with human UNG [J] . Assefa Netsanet Gizaw, Niiranen Laila, Willassen Nils PederSmal?s ArneMoe Elin Comparative biochemistry and physiology, Part B. Biochemistry & molecular biology . 2012,第1期

机译：热冷适应展开研究从大西洋鳕鱼uracil-DNA N-glycosylase ())(Gadus morhua)。
7. Activity of Deinococcus radiodurans on chromium ions [C] . Yunxiao HE, Xiaoming CHEN Global Conference on Civil, Structural and Environmental Engineering . 2012

机译：Deinococcus radiodurans对铬离子的活性
8. Structure-Function Studies of Deinococcus radiodurans Adpglucose Pyrophosphorlyase: Probing the Role of the N-Terminus and Conserved Residues in Regulation of Activity [D] . Ong, Leonard. 2019

机译：Deinococcus radiodurans Adpglucose焦磷酸磷酸酶的结构功能研究：探索N末端和保守残基在调节活动中的作用。
9. Functional and structural characterization of DR_0079 from Deinococcus radiodurans a novel Nudix hydrolase with a preference for cytosine (deoxy)ribonucleoside 5’-di- and triphosphates [O] . Garry W. Buchko, Olga Litvinova, Howard Robinson, -1

机译：Deinococcus radiodurans DR_0079的功能和结构表征Deinococcus radiodurans是一种新型Nudix水解酶偏爱胞嘧啶（脱氧）核糖核苷5-二磷酸和三磷酸酯
10. Correction: Preserving Genome Integrity: The DdrA Protein of Deinococcus radiodurans R1 [O] . Harris, Dennis R, Tanaka, Masashi, Saveliev, Sergei V, 2006

机译：更正：保持基因组完整性：Radiodurans R1的Deinococcus radiodurans R1的DdrA蛋白
11. Characterization of the Effects of Heavy Charged Particle Exposure on the Radiation Resistant Bacterium, Deinococcus Radiodurans. [R] . Bryant, T. A. 2018

机译：重载粒子暴露对辐射抗性细菌Deinococcus Radiodurans影响的表征。

Structure of the uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans

摘要

著录项

相似文献

相关主题

期刊订阅