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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Crystallization and preliminary X-ray crystallographic analysis of macrophage/microglia-specific calcium-binding protein lba1
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Crystallization and preliminary X-ray crystallographic analysis of macrophage/microglia-specific calcium-binding protein lba1

机译：结晶和初步的x射线晶体的分析巨噬细胞/ microglia-specific钙结合蛋白质lba1

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摘要

Iba1 (ionized calcium-binding adaptor molecule 1) is expressed specifically in macrophages/microglia and is involved in the activation of Rac, coordinating the reorganization of the actin cytoskeleton followed by the formation of lamellipodia and membrane ruffles, which are typical properties of activated microglia. Human Iba1 and mouse Iba1 were overexpressed and crystallized. The crystals belong to a monoclinic system, with space group C2 and unit-cell parameters a=60.75, b=36.61, c=99.71 Angstrom, beta=99.71degrees for human Iba1 and a=76.28, b=44.06, c=99.13 Angstrom, beta=90.03degrees for mouse Iba1. Both crystals diffracted well to a resolution of 2.1 Angstrom and initial phase determinations were attempted by a molecular-replacement method using calmodulin structures.
机译：Iba1(电离分子钙结合适配器1)特别是在表示巨噬细胞和小胶质细胞参与激活Rac,协调肌动蛋白细胞骨架重组由板状伪足的形成和膜褶边,这是典型的属性活化的小胶质细胞。是过表达和结晶。属于单斜晶系,空间群C2,晶胞参数= 60.75,b = 36.61,c = 99.71埃,人类β= 99.71度Iba1 = 76.28, = 44.06 b, c = 99.13埃,鼠标Iba1β= 90.03度。衍射分辨率为2.1埃和初始阶段决定尝试由molecular-replacement方法使用钙调蛋白结构。

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