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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >The phase problem.
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The phase problem.

机译：这个阶段的问题。

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Given recent advances in phasing methods, those new to protein crystallography may be forgiven for asking 'what problem?'. As many of those attending the CCP4 meeting come from a biological background, struggling with expression and crystallization, this introductory paper aims to introduce some of the basics that will hopefully make the subsequent papers penetrable. What is the 'phase' in crystallography? What is 'the problem'? How can we overcome the problem? The paper will emphasize that the phase values can only be discovered through some prior knowledge of the structure. The paper will canter through direct methods, isomorphous replacement, anomalous scattering and molecular replacement. As phasing is the most acronymic realm of crystallography, MR, SIR, SIRAS, MIR, MIRAS, MAD and SAD will be expanded and explained in part. Along the way, we will meet some of the heroes of protein crystallography such as Perutz, Kendrew, Crick, Rossmann and Blow who established many of the phasing methods in the UK. It is inevitable that some basic mathematics is encountered, but this will be done as gently as possible.
机译：鉴于最近的进步逐步方法,这些新的蛋白质晶体学可能被原谅问的什么问题?。参加CCP4会议来自生物背景,在表达和苦苦挣扎结晶,这个介绍性的论文旨在希望介绍一些基础知识随后的论文可穿透的。结晶学的“阶段”?问题”?论文将强调的相位值只能通过一些先验知识发现的结构。直接方法、同形替换反常散射和分子替换。定相是最个字母的领域晶体学,先生,先生,SIRAS米尔,米拉,疯了和悲伤的部分将扩展和解释。在这个过程中,我们会遇到一些英雄的蛋白质晶体学如佩鲁茨氏,Kendrew,谁建立了许多克里克,罗斯曼和打击在英国的分阶段方法。遇到一些基本的数学,但这将是完成尽可能的轻。

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