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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Structure of dimeric cytochrome c3 from Desulfovibrio gigas at 1.2 A resolution.
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Structure of dimeric cytochrome c3 from Desulfovibrio gigas at 1.2 A resolution.

机译：二聚的结构细胞色素c3脱磷孤菌属牡蛎在1.2一项决议。

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摘要

The structure of dimeric cytochrome c(3) from the sulfate-reducing bacterium Desulfovibrio gigas, diDg, obtained by ab initio methods was further refined to 1.2 A resolution, giving final reliability factors of R(free) = 14.8% and R = 12.4%. This cytochrome is a dimer of tetraheme cytochrome c(3) molecules covalently linked by two solvent-accessible disulfide bridges, a characteristic unique to members of the cytochrome c(3) superfamily. Anisotropic analysis using the semi-rigid TLS method shows different behaviour for analogous loops in each monomer arising from their different packing environments. A detailed sequence and structural comparison with all other known cytochrome c(3) domains in single- and multi-domain cytochromes c(3) shows the presence of structurally conserved regions in this family, despite the high variability of the amino-acid sequence. An internal water molecule is conserved in a common structural arrangement in all c(3) tetraheme domains, indicating a probable electron-transfer pathway between hemes I and II. Unique features of diDg are an internal methionine residue close to heme I and to one of the axial ligands of heme III, where all other structures of the cytochrome c(3) superfamily have a phenylalanine, and a rather unusual CXXXCH heme-binding motif only found so far in this cytochrome.
机译：二聚的细胞色素c的结构(3)硫酸盐还原细菌脱磷孤菌属牡蛎,进一步diDg,从头开始的方法获得的细化到1.2一项决议,决赛可靠性的因素(免费)= 14.8%,R =12.4%。细胞色素c(3)分子共价相连两个二硫化solvent-accessible桥梁,的成员所特有的特征细胞色素c(3)总科。使用半刚性TLS方法显示不同类似的循环在每个单体的行为因不同的包装环境。与所有其他已知的细胞色素c (3)域在单一和多域细胞色素c(3)显示结构的存在守恒的地区这个家庭,尽管高氨基酸序列的变化。常见的内部水分子是守恒的在所有c (3) tetraheme结构安排域,显示可能的电子转换通路之间的血红素I和II。diDg内部蛋氨酸残渣关闭血红素我和血红素的轴向配体之一第三,所有其他细胞色素的结构c(3)总科有苯丙氨酸,以及非比寻常CXXXCH heme-binding主题发现到目前为止在这个细胞色素。

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