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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Preparation and crystallization of human flap endonuclease FEN-1 in complex with proliferating-cell nuclear antigen, PCNA.
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Preparation and crystallization of human flap endonuclease FEN-1 in complex with proliferating-cell nuclear antigen, PCNA.

机译：准备和人类皮瓣的结晶核酸内切酶FEN-1在复杂proliferating-cell核抗原PCNA。

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摘要

Flap endonuclease-1 (FEN-1) is a structure-specific nuclease that removes 5'-overhanging flaps in DNA repair and replication. FEN-1 binds proliferating-cell nuclear antigen (PCNA), a DNA-clamp protein, when processing Okazaki fragments during lagging-strand DNA synthesis. Here, the crystallization of the complex between human FEN-1 and PCNA is reported. The crystals were found to belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 82.2, b = 143.4, c = 246.7 A, and contained one complex in the crystallographic asymmetric unit. A diffraction data set was collected to a resolution of 3.0 A.
机译：皮瓣endonuclease-1 (FEN-1)是一个structure-specific核酸酶,可去除5 '悬臂襟翼在DNA修复和复制。核抗原(PCNA)、DNA-clamp蛋白质,当处理期间冈崎片段后随链DNA合成。结晶之间复杂的人类FEN-1和PCNA是报道。发现属于空间群P2 (1) 2 (1) 2 (1),晶胞参数= 82.2,= 143.4 b, c= 246.7,包含一个复杂的晶体对称单元。3.0数据集收集的决议。

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